Title
Occupational lung cancer risk among men in the Netherlands
Author
Preller, L.
Balder, H.F.
Tielemans, E.
van den Brandt, P.A.
Goldbohm, R.A.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Objectives: To assess male lung cancer risks for industrial sectors in the Netherlands and to estimate the proportion of lung cancer attributed to working in specific industrial sectors. Methods: Associations were studied among men aged 55-69 years (n = 58 279) from the prospective Netherlands Cohort Study. 1920 incident lung cancer cases were available after 11.3 years of follow-up. Based on a case-cohort design, and using Cox proportional hazards models, risks were estimated for blue collar workers in 26 industrial sectors. Results: Adjustment for individual smoking habits affected risk estimates for some sectors, but adjustment for fruit/vegetables and alcohol intake did not. Adjusted for confounders, an increased risk of lung cancer was observed for employment for ≥15 years in blue collar jobs in the "electronics and optical instruments" industry (rate ratio (RR) 1.99; 95% CI 1.18 to 3.35), "construction and homebuilding business" (RR 1.64; 95% CI 1.21 to 2.22) and "railway company" (RR 2.40; 95% CI 1.00 to 5.73). The attributable fraction for working for ≥15 years in these three industries was 5%. In three other sectors there was a statistically non-significant elevated RR of >1.5. Conclusions: Male lung cancer risk is increased in several industrial sectors. Approximately 2000 lung cancer cases between 1986 and 1997 in the 55-69-year-old age group in the Netherlands may be attributable to working for ≥15 years in the three sectors with increased risk. In addition, estimates for occupational lung cancer risks for sectors may be biased if no individual information is available on smoking habits.
Subject
Health
Food and Chemical Risk Analysis
adult
aged
alcohol consumption
article
blue collar worker
building industry
cancer risk
cohort analysis
confidence interval
electronics industry
employment
follow up
food intake
fruit
human
incidence
industry
lifestyle
lung cancer
major clinical study
male
Netherlands
occupational lung disease
optical instrumentation
priority journal
proportional hazards model
prospective study
railway employee
risk assessment
risk factor
smoking habit
statistical significance
vegetable
Aged
Alcohol Drinking
Epidemiologic Methods
Food Habits
Fruit
Humans
Industry
Lung Neoplasms
Male
Middle Aged
Netherlands
Occupational Diseases
Occupational Exposure
Smoking
Time Factors
Vegetables
To reference this document use:
http://resolver.tudelft.nl/uuid:9522ae18-68ea-4760-9b37-1ecc48a842ef
DOI
https://doi.org/10.1136/oem.2006.030353
TNO identifier
240734
ISSN
1351-0711
Source
Occupational and Environmental Medicine, 65 (4), 249-254
Document type
article