Title
Immunological functions and in vivo cell-cell interactions of T cells in the spleen
Author
van den Eertwegh, A.J.M.
Boersma, W.J.A.
Claassen, E.
Medisch Biologisch Laboratorium TNO
Publication year
1992
Abstract
The spleen is an important lymphoid organ, involved in immune responses against all types of antigen that appear in the circulation. Its complex anatomical organization, with distinct compartments containing specialized cell types, provides a microenvironment which allows different cell-cell interactions and determines the direction of developing immune responses. In this review we evaluate the vast amount of in vitro data dealing with antigen presentation, cell-cell interactions, T and B cell activation, and the immunoregulatory role of cytokines, as suggested to be involved in immune responses. As a basis for understanding of in vivo processes, these in vitro data will be related to discrete phenomena of in vivo immune responses, such as antigen localization/trapping, cell migration patterns of immunocompetent cells, cytokine production, and antibody formation in the different compartments of the spleen. Finally, we try to bring order to the sequence of events that occur in the spleen after antigenic challenge by presenting an in vivo model for T cell dependent and T cell independent immune responses.
Subject
Accessory cells
Antibody-forming cells
Antigen
cells
Cell-cell interactions
Cytokines
Localization
Migration
T cells
Antigen
Cytokine
Antibody production
Antigen detection
Antigen presentation
Antigen recognition
B lymphocyte
B lymphocyte activation
Cell interaction
Cell migration
Cellular distribution
Cellular immunity
Gene expression
Immune response
Infection
Macrophage
Major histocompatibility complex
Natural killer cell
Priority journal
Review
Spleen
T lymphocyte
T lymphocyte activation
Animal
Antibody Formation
Antigen-Presenting Cells
Antigens
B-Lymphocytes
Cell Communication
Cell Movement
Cytokines
Dendritic Cells
Gene Expression Regulation
Human
Infection
Lymphocyte Activation
Mice
Mice, Inbred Strains
Rats
Spleen
T-Lymphocytes
T-Lymphocytes, Helper-Inducer
To reference this document use:
http://resolver.tudelft.nl/uuid:94d1f65a-0642-4c30-9775-cc07d7f971e5
TNO identifier
231778
ISSN
1040-8401
Source
Critical Reviews in Immunology, 11 (6), 337-380
Bibliographical note
Correspondence Address: Van den Eertwegh, A.J.M.; TNO Medical Biological Laboratory, Immunol./Medical Microbiology Dept., P.O. Box 45, 2280 AA Rijswijk, Netherlands Chemicals/CAS: Antigens; Cytokines
Document type
article