Print Email Facebook Twitter Immunological functions and in vivo cell-cell interactions of T cells in the spleen Title Immunological functions and in vivo cell-cell interactions of T cells in the spleen Author van den Eertwegh, A.J.M. Boersma, W.J.A. Claassen, E. Medisch Biologisch Laboratorium TNO Publication year 1992 Abstract The spleen is an important lymphoid organ, involved in immune responses against all types of antigen that appear in the circulation. Its complex anatomical organization, with distinct compartments containing specialized cell types, provides a microenvironment which allows different cell-cell interactions and determines the direction of developing immune responses. In this review we evaluate the vast amount of in vitro data dealing with antigen presentation, cell-cell interactions, T and B cell activation, and the immunoregulatory role of cytokines, as suggested to be involved in immune responses. As a basis for understanding of in vivo processes, these in vitro data will be related to discrete phenomena of in vivo immune responses, such as antigen localization/trapping, cell migration patterns of immunocompetent cells, cytokine production, and antibody formation in the different compartments of the spleen. Finally, we try to bring order to the sequence of events that occur in the spleen after antigenic challenge by presenting an in vivo model for T cell dependent and T cell independent immune responses. Subject Accessory cellsAntibody-forming cellsAntigencellsCell-cell interactionsCytokinesLocalizationMigrationT cellsAntigenCytokineAntibody productionAntigen detectionAntigen presentationAntigen recognitionB lymphocyteB lymphocyte activationCell interactionCell migrationCellular distributionCellular immunityGene expressionImmune responseInfectionMacrophageMajor histocompatibility complexNatural killer cellPriority journalReviewSpleenT lymphocyteT lymphocyte activationAnimalAntibody FormationAntigen-Presenting CellsAntigensB-LymphocytesCell CommunicationCell MovementCytokinesDendritic CellsGene Expression RegulationHumanInfectionLymphocyte ActivationMiceMice, Inbred StrainsRatsSpleenT-LymphocytesT-Lymphocytes, Helper-Inducer To reference this document use: http://resolver.tudelft.nl/uuid:94d1f65a-0642-4c30-9775-cc07d7f971e5 TNO identifier 231778 ISSN 1040-8401 Source Critical Reviews in Immunology, 11 (6), 337-380 Bibliographical note Correspondence Address: Van den Eertwegh, A.J.M.; TNO Medical Biological Laboratory, Immunol./Medical Microbiology Dept., P.O. Box 45, 2280 AA Rijswijk, Netherlands Chemicals/CAS: Antigens; Cytokines Document type article Files To receive the publication files, please send an e-mail request to TNO Library.