Title
Evaluation of the Retrievability of the OptEase IVC Filter in an Animal Model
Author
Reekers, J.A.
Hoogeveen, Y.L.
Wijnands, M.
Bosma, G.
Mulder, R.
Oliva, V.L.
TNO Voeding
Publication year
2004
Abstract
PURPOSE: A new inferior vena cava filter was evaluated in vivo to determine the percutaneous retrievability after an implantation period of up to 18 days. MATERIALS AND METHODS: The inferior venae cavae of six goats were percutaneously implanted with three filters, and one animal received two filters. To assess filter stability, a plain radiograph was obtained after 7-9 days and on the day of retrieval. After cavography, filter retrieval with an endovascular snare and retrieval catheter was performed in three animals after 12 days and in three others after 14 days. In one animal, retrieval of one filter was performed after 18 days, and one filter was intended to be permanent. Twenty-eight days after filter retrieval, cavography was performed before inferior vena cava removal for gross and histologic examination. RESULTS: All filters (N = 20) were implanted without complications. There was no migration during the implantation period. Preretrieval cavography demonstrated all filters to be patent and centered. Filters intended for retrieval (n = 19) were all successfully extracted at 12 (nine filters), 14 (nine filters), and 18 days (one filter). For the animal with the filter extracted at 18 days, one filter remained in situ intentionally. Postretrieval cavography showed no visible signs of vessel wall anomalies. There were no complications during the 28 days of follow-up after retrieval. Presacrifice cavography showed no evidence of caval wall abnormalities. In all animals, gross examination of the inner wall of the explanted vena cava showed only minimal macroscopic changes. The struts of the filter in situ for 46 days (18 days with 28 days of follow-up) were overgrown with neointima. Histological study of the 19 filter retrieval sites revealed no to moderate intima proliferation, minimal residual signs of hemorrhages, and no or only occasional slight inflammatory reaction. CONCLUSIONS: In this animal model, the new vena cava filter demonstrated event-free retrieval, without postretrieval complications, up to 18 days postimplantation. After implantation of 46 days, the filter showed neointima overgrowth of the struts.
Subject
Biology
Toxicology and Applied Pharmacology
adolescent
animal model
animal tissue
artery intima proliferation
article
bleeding
catheter
cavography
device
device removal
device retrieval
endovascular snare
female
goat
histology
implantation
inferior cava vein
inflammation
nonhuman
percutaneous implantation
priority journal
radiography
retrieval catheter
technique
vein wall
vena cava filter
Animals
Catheterization, Central Venous
Device Removal
Goats
Models, Animal
Surface Properties
Time Factors
Tunica Intima
Vascular Patency
Vasculitis
Vena Cava Filters
Vena Cava, Inferior
To reference this document use:
http://resolver.tudelft.nl/uuid:9489d788-8406-4a4d-bf0c-027b7d3db1e9
TNO identifier
237655
ISSN
1051-0443
Source
Journal of Vascular and Interventional Radiology, 15 (3), 261-267
Document type
article