Title
Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables
Author
Rad, M.
Kluft, C.
Ménard, J.
Burggraaf, J.
de Kam, M.L.
Meijer, P.
Sivin, I.
Sitruk-Ware, R.L.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Objective: This study aimed to compare the effects on hemostasis variables of a contraceptive vaginal ring with those of an oral contraceptive. Study design: Twenty-three and 22 healthy premenopausal women were randomized to the contraceptive vaginal ring (150 μg Nestorone and 15 μg ethinyl estradiol) or Stediril 30 during 3 cycles. Analysis of covariance was performed with baseline values as covariate. Results: The contraceptive vaginal ring changed most hemostasis variables similarly but raised (95% confidence intervals of percent treatment differences) Factor VIIt (28% to 49%), extrinsic activated protein C resistance (14% to 65%), and sex hormone-binding globulin (117% to 210%) and lowered Protein S (-32% to -16%) and the global activated partial thromboplastin time-based activated protein C resistance (-12% to -2%) more than the oral contraceptive. Conclusion: The contraceptive vaginal ring affected some measured hemostasis variables and sex hormone-binding globulin differently from the oral contraceptive, most likely because of difference in androgenicity of the progestins. The results suggest that the contraindications for oral contraceptive use would also apply to the tested contraceptive vaginal ring. © 2006 Mosby, Inc. All rights reserved. Chemicals / CAS: blood clotting factor 7, 9001-25-6; elcometrine, 7759-35-5; ethinylestradiol plus norgestrel, 8056-51-7; ethinylestradiol, 57-63-6; levonorgestrel, 797-63-7; Blood Coagulation Factors; Contraceptive Agents, Female; Contraceptives, Oral, Combined; Estrogens; Ethinyl Estradiol, 57-63-6; Ethinyl Estradiol-Norgestrel Combination, 8056-51-7; Norprogesterones; Plasminogen, 9001-91-6; Protein C; Sex Hormone-Binding Globulin; ST 1435, 7759-35-5
Subject
Biology
Biomedical Research
Coagulation
Contraceptive vaginal ring
Nestorone
Oral contraceptives
Venous thromboembolism
blood clotting factor 7
elcometrine
ethinylestradiol
ethinylestradiol plus norgestrel
gestagen
levonorgestrel
oral contraceptive agent
protein S
activated protein C resistance
analysis of variance
confidence interval
contraception
drug effect
hemostasis
partial thromboplastin time
vagina ring
vaginal delivery
Activated Protein C Resistance
Adolescent
Adult
Blood Coagulation Factors
Contraceptive Agents, Female
Contraceptive Devices, Female
Contraceptives, Oral, Combined
Estrogens
Ethinyl Estradiol
Ethinyl Estradiol-Norgestrel Combination
Female
Fibrinolysis
Humans
Immunoradiometric Assay
Norprogesterones
Plasminogen
Protein C
Sex Hormone-Binding Globulin
To reference this document use:
http://resolver.tudelft.nl/uuid:94831182-47a5-4d64-961d-be38855d18a4
DOI
https://doi.org/10.1016/j.ajog.2005.12.007
TNO identifier
239344
ISSN
0002-9378
Source
American Journal of Obstetrics and Gynecology, 195 (1), 72-77
Document type
article