Trehalose: A review of properties, history of use and human tolerance, and results of multiple safety studies

Trehalose: A review of properties, history of use and human tolerance, and results of multiple safety studies

Richards, A.B.
Krakowka, S.
Dexter, L.B.
Schmid, H.
Wolterbeek, A.P.M.
Waalkens-Berendsen, D.H.
Shigoyuki, A.
Kurimoto, M.
Instituut CIVO-Toxicologie en Voeding TNO

2002

This paper contains a review of the history, natural occurrence, human consumption, metabolism, manufacture, and the results of eight standardized animal safety studies using trehalose. Trehalose (α,α-trehalose) is a naturally occurring sugar containing two D-glucose units in an α,α-1,1 linkage. Trehalose functions in many organisms as an energy source or a protectant against the effects of freezing or dehydration. It also possesses physical and/or chemical properties that are different than other sugars, which may make trehalose an attractive ingredient in food, health and beauty and pharmaceutical products. Data are presented supporting safe human consumption of trehalose in doses up to 50 g, and the physiologic ability of humans to digest it. No consistent treatment-related, dose-dependent adverse effects were observed in any of the eight safety studies performed at doses up to 10% of the diets. On the basis of these toxicity studies, human studies in which doses of trehalose were administered to various populations, and consumption of trehalose in commercial products in Japan, it is concluded that trehalose is safe for use as an ingredient in consumer products when used in accordance with current Good Manufacturing Practices. © 2002 Elsevier Science Ltd. All rights reserved. Chemicals/CAS: Trehalose, 99-20-7

Nutrition
Animals
Female
Humans
Male
Toxicity Tests
Trehalose
Animalia

http://resolver.tudelft.nl/uuid:938a9cf9-e4ad-4b52-afb1-e171da36aff6

https://doi.org/10.1016/s0278-6915(02)00011-x

42381

0278-6915

Food and Chemical Toxicology, 40 (7), 871-898

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