Title
Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus
Author
Myrup, B.
Hansen, P.M.
Jensen, T.
Kofoed-Enevoldsen, A.
Feldt-Rasmussen, B.
Gram, J.
Kluft, C.
Jespersen, J.
Deckert, T.
Gaubius Instituut TNO
Publication year
1995
Abstract
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.
Subject
Biology
albumin
heparin
isotonic solution
sodium chloride
adult
clinical article
clinical trial
controlled clinical trial
controlled study
female
human
insulin dependent diabetes mellitus
proteinuria
randomized controlled trial
subcutaneous drug administration
Adult
Albuminuria
Diabetes Mellitus, Type 1
Female
Heparin
Heparin, Low-Molecular-Weight
Humans
Male
Middle Aged
Treatment Outcome
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DOI
https://doi.org/10.1016/s0140-6736(95)90403-4
TNO identifier
232953
ISSN
0140-6736
Source
Lancet, 345 (8947), 421-422
Document type
article