Print Email Facebook Twitter Tapering of the interventricular septum can affect ultrasound shear wave elastography Title Tapering of the interventricular septum can affect ultrasound shear wave elastography: An in vitro and in silico study Author Sabbadini, A. Caenen, A. Keijzer, L.B.H. van Neer, P.L. Vos, H.J. de Jong, N. Verweij, M.D. Publication year 2021 Abstract Shear wave elastography (SWE) has the potential to determine cardiac tissue stiffness from non-invasive shear wave speed measurements, important, e.g., for predicting heart failure. Previous studies showed that waves traveling in the interventricular septum (IVS) may display Lamb-like dispersive behaviour, introducing a thickness-frequency dependency in the wave speed. However, the IVS tapers across its length, which complicates wave speed estimation by introducing an additional variable to account for. The goal of this work is to assess the impact of tapering thickness on SWE. The investigation is performed by combining in vitro experiments with acoustic radiation force (ARF) and 2D finite element simulations, to isolate the effect of the tapering curve on ARF-induced and natural waves in the heart. The experiments show a 11% deceleration during propagation from the thick to the thin end of an IVSmimicking tapered phantom plate. The numerical analysis shows that neglecting the thickness variation in the wavenumber-frequency domain can introduce errors of more than 30% in the estimation of the shear modulus, and that the exact tapering curve, rather than the overall thickness reduction, determines the dispersive behaviour of the wave. These results suggest that septal geometry should be accounted for when deriving cardiac stiffness with SWE. Subject Dispersion (waves)Frequency domain analysisFrequency estimationHeartMedical imagingShear wavesStiffnessUltrasonics2D finite element simulationAcoustic radiation forceShear wave elastographyShear wave speedThickness frequenciesThickness reductionThickness variationWavenumber-frequency domainShear flowanimalcomputer simulationechographyelastographyheartimaging phantomAnimalsComputer SimulationElasticity Imaging TechniquesHeartPhantoms, ImagingSheepUltrasonography To reference this document use: http://resolver.tudelft.nl/uuid:92a1eeed-e4d9-434c-8b74-7694e7061264 TNO identifier 967825 Publisher Acoustical Society of America ISSN 0001-4966 Source Journal of the Acoustical Society of America, 150 (150), 428-440 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.