Print Email Facebook Twitter Moderate Alcohol Consumption and Insulin Sensitivity: Observations and Possible Mechanisms Title Moderate Alcohol Consumption and Insulin Sensitivity: Observations and Possible Mechanisms Author Hendriks, H.F.J. TNO Kwaliteit van Leven Publication year 2007 Abstract Light to moderate alcohol consumption is associated with a reduced risk for cardiovascular diseases. Epidemiologic studies, like our analysis of the European Prospective Investigation into Cancer and Nutrition study, suggest that moderate alcohol consumption is also associated with a reduced risk of type 2 diabetes, reported for various populations. This risk reduction may be explained by an increase in insulin sensitivity after moderate alcohol consumption. Indeed, a positive association between alcohol consumption and insulin sensitivity is consistently reported in cross-sectional studies. Mechanisms for the effect of alcohol on insulin sensitivity may include modulation of changes in the endocrine functioning of fat tissue, modulation of the inflammatory status of several organs, and/or modulation of glucose and fatty acid metabolism. © 2007 Elsevier Inc. All rights reserved. Subject Biomedical ResearchAdiponectinAlcohol DrinkingDiabetes MellitusEpidemiologyHumanInsulinMechanismNutrition Interventionfatty acidglucoseinsulinadipose tissuealcohol consumptionarticlecardiovascular diseasecardiovascular riskendocrine functionfatty acid metabolismglucose metabolismhumaninsulin sensitivitymodulationnon insulin dependent diabetes mellituspriority journal To reference this document use: http://resolver.tudelft.nl/uuid:91792ab5-4a32-4b7c-8306-b3f5cbf0d197 DOI https://doi.org/10.1016/j.annepidem.2007.01.009 TNO identifier 239959 ISSN 1047-2797 Source Annals of Epidemiology, 17 (5 SUPPL.) Document type article Files To receive the publication files, please send an e-mail request to TNO Library.