Title
Adverse effects of Pentachlorophenol on fertility and reproduction: a literature study
Author
Instituut CIVO-Toxicologie en Voeding TNO
Koëter, H.B.W.M.
Blijleven, W.G.H.
Dreef-van der Meulen, H.C.
Stijkel, A.
Zielhuis, R.L.
Publication year
1989
Abstract
According to a study in animals described by Schwetz et al. (1974), pentachlorophenol induces embryotoxic and teratogenic effects whereas Welsh et al. (1987) reported embryolethal effects. Further any animal and human data with respect to endocrine system, gonads and fertility are lacking. Data on offspring are inadequate for evaluation. It is therefore concluded that a NEAL could not be assessed and that further studies are necessary. There is reason to reassess the present MAC (0.5 mg/m3).
Subject
Historisch materiaal TNO
Proefdieren
Voortplanting
Vruchtbaarheid
Onvruchtbaarheid
MAC
Maximaal aanvaarde concentratie
Teratogenese
Epidemiologie
Pentachloorfenol
PCP
To reference this document use:
http://resolver.tudelft.nl/uuid:914176f7-a1f9-43a3-8ada-ff43a14a4f05
TNO identifier
160906
Report number
Ser. 4, S 73-5
Publisher
Min. SZW, Arbeidsinspectie ; DGA, Den Haag
ISBN
9053070095
ISSN
0921-9218
Series
Studie
Document type
book