Title
A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice
Author
Muurling, M.
Jong, M.C.
Mensink, R.P.
Hornstra, G.
Dahlmans, V.E.H.
Pijl, H.
Voshol, P.J.
Havekes, L.M.
Gaubius Instituut TNO
Publication year
2002
Abstract
Previous studies have shown that energy restriction (ER) or low-fat (LF) diets have beneficial effects on high-fat (HF) diet-induced obesity and non-insulin-dependent diabetes. However, comparison between ER and low-fat diet regarding the effect on insulin resistance and lipid metabolism has not been reported. After inducing insulin resistance by HF feeding for 20 weeks, male C57BL/6J mice were divided into 3 groups. For a period of 12 weeks, group 1 received energy restriction (70% of ad libitum, HF diet), group 2 LF diet, and group 3 maintained on HF diet. Body weight and energy intake were reduced equally in ER and LF feeding. Plasma insulin levels were decreased on LF feeding, but were unchanged on ER, when compared with HF feeding. Glucose tolerance and insulin sensitivity tests revealed that insulin sensitivity was improved more efficiently by LF feeding than on ER. Plasma triglyceride (TG) levels were lower on LF feeding compared with ER and HF feeding. Measurement of hepatic very-low-density lipoprotein (VLDL)-TG production revealed a lower production after LF diet feeding or ER compared with HF diet feeding. In summary, our data show that LF diet has a higher potential than ER to improve HF diet-induced insulin resistance, and that there is an association between improvement of insulin resistance and decrease of TG levels. Copyright 2002, Elsevier Science (USA). All rights reserved.
Subject
Biology Health
fat
fatty acid
glucose
high density lipoprotein
insulin
intermediate density lipoprotein
low density lipoprotein
triacylglycerol
very low density lipoprotein
animal experiment
animal model
article
body weight
caloric intake
controlled study
energy metabolism
feeding
glucose tolerance
insulin blood level
insulin dependent diabetes mellitus
insulin resistance
insulin sensitivity
lipid diet
lipid metabolism
low fat diet
male
mouse
non insulin dependent diabetes mellitus
nonhuman
obesity
priority journal
Animals
Blood Glucose
Body Weight
Cholesterol
Dietary Fats
Energy Intake
Fatty Acids, Nonesterified
Glucose Tolerance Test
Insulin
Insulin Resistance
Lipids
Lipoproteins
Lipoproteins, VLDL
Liver
Male
Mice
Mice, Inbred C57BL
Polyethylene Glycols
Triglycerides
To reference this document use:
http://resolver.tudelft.nl/uuid:9116c6fb-3b2f-4a74-a54e-ebeaddf944f8
DOI
https://doi.org/10.1053/meta.2002.32725
TNO identifier
236575
ISSN
0026-0495
Source
Metabolism: Clinical and Experimental, 51 (6), 695-701
Document type
article