Print Email Facebook Twitter Acute and chronic effects of dinner with alcoholic beverages on nitric oxide metabolites in healthy men Title Acute and chronic effects of dinner with alcoholic beverages on nitric oxide metabolites in healthy men Author Sierksma, A. van der Gaag, M.S. Grobbee, D.E. Hendriks, H.F.J. Publication year 2003 Abstract 1. The present study investigated the acute and chronic effect of dinner with alcoholic beverages on serum nitric oxide (NO) metabolites, namely nitrate and nitrite (NOx), in 11 healthy, non-smoking middle-aged men. 2. In a randomized, diet-controlled, cross-over trial, subjects consumed dinner with four glasses of red wine, beer, spirits (Dutch gin) or sparkling mineral water (control) for 3 weeks. At the end of each 3 week period, serum NOx concentrations were measured just before and 1, 5 and 13 h after dinner. 3. Serum NOx concentrations were approximately 50% higher 1 and 5 h after dinner with any beverage compared with just before dinner (P = 0.0001). At 1 h after dinner, the serum NOx concentration was approximately 11% lower after dinner with alcoholic beverages compared with concentrations observed after dinner with water (P = 0.01). The fasted serum NOx concentration (13 h after dinner) was similar to the preprandial concentration and there were no differences in serum NOx concentrations between the alcoholic beverages. 4. Food intake acutely and transiently increased serum NOx concentrations, an effect that was slightly attenuated if combined with alcoholic beverages. Chronic moderate alcohol consumption had no effect on serum NOx concentration. Subject HealthPhysiological SciencesEthanolFoodNitrateNitric oxideNitritemineral waternitratenitric oxidenitriteadultalcoholic beverageanalysis of variancearticlebeerbloodblood levelcigarette smokingclinical trialcomparative studycontrolled clinical trialcontrolled studycrossover proceduredrinking behavioreatingfood intakeginhumanmalemealnormal humanphysiologypostprandial staterandomizationrandomized controlled trialtimewineAdultAlcohol DrinkingAlcoholic BeveragesAnalysis of VarianceCross-Over StudiesEatingHumansMaleMiddle AgedNitric OxidePostprandial PeriodTime Factors To reference this document use: http://resolver.tudelft.nl/uuid:8d8e025e-1714-4806-a9a2-952e4071ac0e DOI https://doi.org/10.1046/j.1440-1681.2003.03863.x TNO identifier 237155 ISSN 0305-1870 Source Clinical and Experimental Pharmacology and Physiology, 30 (7), 504-506 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.