Title
Acute and chronic effects of dinner with alcoholic beverages on nitric oxide metabolites in healthy men
Author
Sierksma, A.
van der Gaag, M.S.
Grobbee, D.E.
Hendriks, H.F.J.
Publication year
2003
Abstract
1. The present study investigated the acute and chronic effect of dinner with alcoholic beverages on serum nitric oxide (NO) metabolites, namely nitrate and nitrite (NOx), in 11 healthy, non-smoking middle-aged men. 2. In a randomized, diet-controlled, cross-over trial, subjects consumed dinner with four glasses of red wine, beer, spirits (Dutch gin) or sparkling mineral water (control) for 3 weeks. At the end of each 3 week period, serum NOx concentrations were measured just before and 1, 5 and 13 h after dinner. 3. Serum NOx concentrations were approximately 50% higher 1 and 5 h after dinner with any beverage compared with just before dinner (P = 0.0001). At 1 h after dinner, the serum NOx concentration was approximately 11% lower after dinner with alcoholic beverages compared with concentrations observed after dinner with water (P = 0.01). The fasted serum NOx concentration (13 h after dinner) was similar to the preprandial concentration and there were no differences in serum NOx concentrations between the alcoholic beverages. 4. Food intake acutely and transiently increased serum NOx concentrations, an effect that was slightly attenuated if combined with alcoholic beverages. Chronic moderate alcohol consumption had no effect on serum NOx concentration.
Subject
Health
Physiological Sciences
Ethanol
Food
Nitrate
Nitric oxide
Nitrite
mineral water
nitrate
nitric oxide
nitrite
adult
alcoholic beverage
analysis of variance
article
beer
blood
blood level
cigarette smoking
clinical trial
comparative study
controlled clinical trial
controlled study
crossover procedure
drinking behavior
eating
food intake
gin
human
male
meal
normal human
physiology
postprandial state
randomization
randomized controlled trial
time
wine
Adult
Alcohol Drinking
Alcoholic Beverages
Analysis of Variance
Cross-Over Studies
Eating
Humans
Male
Middle Aged
Nitric Oxide
Postprandial Period
Time Factors
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DOI
https://doi.org/10.1046/j.1440-1681.2003.03863.x
TNO identifier
237155
ISSN
0305-1870
Source
Clinical and Experimental Pharmacology and Physiology, 30 (7), 504-506
Document type
article