Print Email Facebook Twitter Betaine supplementation lowers plasma homocysteine in healthy men and women Title Betaine supplementation lowers plasma homocysteine in healthy men and women Author Steenge, G.R. Verhoef, P. Katan, M.B. Publication year 2003 Abstract Elevated levels of plasma total homocysteine are associated with a higher risk of cardiovascular disease. Betaine and 5-methyltetrahydrofolate can remethylate homocysteine into methionine via independent reactions. We determined the effect of daily betaine supplementation, compared with both folic acid and placebo, on plasma concentrations of total homocysteine after an overnight fast and after methionine loading in men and women with mildly elevated homocysteine. Groups of twelve subjects ingested 6 g betaine, 800 μg folic acid with 6 g placebo or 6 g placebo each day for 6 wk. A methionine-loading test (i.e., ingestion of 100 mg L-methionine/kg body mass) was performed before and after 6 wk of supplementation. Fasting plasma homocysteine decreased by 1.8 μmol/L (95% confidence interval [CI]; -3.6, 0.0, P < 0.05) in the betaine group and by 2.7 μmol/L (95% CI: -4.5, -0.9, P < 0.05) in the folic acid group. These changes are relative to the change in the placebo group, in which fasting plasma homocysteine rose by 0.5 μmol/L. Furthermore, betaine suppressed the total area under the plasma homocysteine-time curve after methionine loading by 221 μmol. 24 h/L (95% CI: -425, -16, P < 0.05) compared with placebo, whereas folic acid had no effect. In conclusion, betaine appears to be highly effective in preventing a rise in plasma homocysteine concentration after methionine intake in subjects with mildly elevated homocysteine. It is not known whether this potential of betaine to "stabilize" circulating homocysteine concentrations lowers the risk of cardiovascular disease. Subject HealthPhysiological SciencesBetaineFolic acidHomocysteine metabolismIntervention studyMethionine-loading test5 methyltetrahydrofolic acidbetainehomocysteinemethionineplaceboadultamino acid blood levelamino acid metabolismarea under the curvearticlebody masscardiovascular diseasecardiovascular riskclinical trialcontrolled clinical trialcontrolled studydiet restrictiondiet supplementationdrug efficacyfemalehumanloading testmalerandomized controlled trialAdultBetaineBlood GlucoseBlood PressureBody Mass IndexDietDietary SupplementsEatingFastingFemaleFolic AcidHomocysteineHumansLipidsMaleReference Values To reference this document use: http://resolver.tudelft.nl/uuid:8bc2afae-787a-4117-b747-435bcd0ca7a1 TNO identifier 237055 ISSN 0022-3166 Source Journal of Nutrition, 133 (5), 1291-1295 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.