Title
The reticuloendothelial system and aging: A review
Author
Instituut voor experimentele gerontologie TNO
Brouwer, A.
Knook, D.L.
Publication year
1983
Abstract
This review represents an attempt to summarize and evaluate the literature data on the changes occurring in the reticuloendothelial system (RES) during aging. The RES is briefly introduced with emphasis on cellular composition, function, physiology, regulation and the methods employed for assessment of its functions. The age-related changes in the RES are discussed in terms of endocytotic capacity, antimicrobial and antitumor activity and morphology. In addition, the cooperation between the RES and the immune system in the defence of the body against disease agents is discussed in relation to the increased susceptibility to infectious diseases and tumorigenesis in both man and experimental animals during aging. Chemicals/CAS: Colloids
Subject
aged
carcinogenesis
colloid clearance
etiology
host resistance
infection
macrophage
normal human
reticuloendothelial system
review
Aging
Animal
Carcinoma, Ehrlich Tumor
Colloids
Endocytosis
Guinea Pigs
Human
Immunity, Natural
Kinetics
Macrophages
Mice
Neoplasm Metastasis
Phagocytosis
Rabbits
Rats
Reticuloendothelial System
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DOI
https://doi.org/10.1016/0047-6374(83)90042-8
TNO identifier
229474
ISSN
0047-6374
Source
Mechanisms of Ageing and Development, 21 (21), 205-228
Document type
article