Print Email Facebook Twitter CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-γ production and increased sensitivity to dexamethasone Title CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-γ production and increased sensitivity to dexamethasone Author Visser, J. Blauw, B. Hinloopen, B. Brommer, E. Ronald De Kloet, E. Kluft, C. Nagelkerken, L. TNO Preventie en Gezondheid Publication year 1998 Abstract A disturbed hypothalamus-pituitary-adrenal gland axis and alterations at the immune system level have been observed in patients with chronic fatigue syndrome (CFS). Glucocorticoids are known to modulate T cell responses; therefore, purified CD4 T cells from CFS patients were studied to determine whether they have an altered sensitivity to dexamethasone (DEX). CD4 T cells from CFS patients produced less interferon-γ than did cells from controls; by contrast, interleukin-4 production and cell proliferation were comparable. With CD4 T cells from CFS patients (compared with cells from controls), a 10- to 20-fold lower DEX concentration was needed to achieve 50% inhibition of interleukin-4 production and proliferation, indicating an increased sensitivity to DEX in CFS patients. Surprisingly, interferon-γ production in patients and controls was equally sensitive to DEX. A differential sensitivity of cytokines or CD4 T cell subsets to glucocorticoids might explain an altered immunologic function in CFS patients. Subject PharmacologyAdultCD4-Positive T-LymphocytesCell DivisionCells, CulturedDexamethasoneFatigue Syndrome, ChronicGlucocorticoidsHumansInterferon Type IIInterleukin-4Middle AgedTh1 Cells To reference this document use: http://resolver.tudelft.nl/uuid:8ac18ebd-4b57-4508-a823-cbabb4c7cccc TNO identifier 234375 ISSN 0022-1899 Source Journal of Infectious Diseases, 177 (2), 451-454 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.