Print Email Facebook Twitter Allele-specific expression of the IL-1 gene in human CD4 + T cell clones Title Allele-specific expression of the IL-1 gene in human CD4 + T cell clones Author Gaubius Instituut TNO Bayley, J.P. van Rietschoten, J.G.I. Bakker, A.M. van Baarsen, L. Kaijzel, E.L. Wierenga, E.A. van der pouw Kraan, T.C.T.M. Huizinga, T.W.J. Verweij, C.L. Publication year 2003 Abstract A number of reports have described the monoallelic expression of murine cytokine genes. Here we describe the monoallelic expression of the human IL-1? gene in CD4+ T cells. Analysis of peripheral blood T cell clones derived from healthy individuals revealed that the IL-1? gene shows predominantly monoallelic expression. Monoallelic expression was observed in Th0, Th1, and Th2 cell clones. In addition, we demonstrate monoallelic expression in T cell clones from rheumatoid arthritis patients derived from synovial fluid of the knee joint, suggesting that the occurrence of this phenomenon is not different from that in clones derived from healthy individuals. The finding of monoallelic expression of a cytokine gene in human CD4+ T cell clones provides evidence for allele-specific silencing/activation as another layer of regulation of IL-1? gene expression. Subject interleukin 1alphaallelearticlecell clonecontrolled studygene controlgene expressionhumanhuman cellrheumatoid arthritissynovial fluidT lymphocyteTh1 cellTh2 cell To reference this document use: http://resolver.tudelft.nl/uuid:8a2af3bb-915b-4cd7-8b0e-a25e90ff38ed DOI https://doi.org/10.4049/jimmunol.171.5.2349 TNO identifier 953665 ISSN 0022-1767 Source Journal of Immunology, 171 (171), 2349-2353 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.