Print Email Facebook Twitter Alcohol in combination with malnutrition causes increased liver fibrosis in rats Title Alcohol in combination with malnutrition causes increased liver fibrosis in rats Author Bosma, A. Seifert, W.F. de Thiel van - Ruiter, G.C.F. van Leeuwen, R.E.W. Blauw, B. Roholl, P. Knook, D.L. Brouwer, A. Gaubius Laboratory TNO Preventie en Gezondheid Instituut voor verouderings- en vaatziekten onderzoek TNO Publication year 1994 Abstract Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in drinking water available ad libitum, the livers of all eight rats showed increased fibrosis and cirrhosis as compared to the livers of the eight non-alcohol-treated, isocalorically fed, paired control rats. Alcohol-treated rats developed fibrosis and cirrhosis on a dietary fat content of 38% of total caloric intake and low blood alcohol levels, ranging from 50 to 126 mg/dl, due to gradual intake over the day and to low absolute intake (mean 11.9±0.6 g/kg per day). None of the rats died spontaneously. Malnutrition is likely to be an important factor in the development of the fibrosis of alcoholic liver disease, and this rat model may be used to study aspects of the pathogenesis. Chemicals/CAS: Alanine Transaminase, EC 184.108.40.206; Aspartate Aminotransferases, EC 220.127.116.11; Cholesterol, 57-88-5; Dietary Fats; Ethanol, 64-17-5; gamma-Glutamyltransferase, EC 18.104.22.168; Triglycerides Subject BiologyAlcoholic liver diseaseCirrhosisFibrosisMalnutritionRatalcoholalcohol liver diseaseanimal experimentanimal tissuecaloric intakecontrolled studyelectron microscopyfat intakehistologyliver fibrosismalemalnutritionnonhumanpathogenesisAlanine TransaminaseAlcoholismAnimalAspartate AminotransferasesCholesterolDietary FatsDisease Models, AnimalEthanolFood, Formulatedgamma-GlutamyltransferaseLiverLiver Cirrhosis, AlcoholicLiver Cirrhosis, ExperimentalMaleMicroscopy, ElectronNutrition DisordersRatsTriglycerides To reference this document use: http://resolver.tudelft.nl/uuid:8a0861c3-f972-4f99-8cfd-7ddc0c2b7d7d DOI https://doi.org/10.1016/s0168-8278(05)80319-8 TNO identifier 232692 ISSN 0168-8278 Source Journal of Hepatology, 21 (3), 394-402 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.