Print Email Facebook Twitter The relation between neonatal thyroxine levels and neurodevelopmental outcome at age 5 and 9 years in a national cohort of very preterm and/or very low birth weight infants Title The relation between neonatal thyroxine levels and neurodevelopmental outcome at age 5 and 9 years in a national cohort of very preterm and/or very low birth weight infants Author den Ouden, A.L. Kok, J.H. Verkerk, P.H. Brand, R. Verloove-Vanhorick, S.P. TNO Preventie en Gezondheid Publication year 1996 Abstract Transient neonatal hypothyroxinemia is very common in preterm infants. The literature on the effect of this hypothyroxinemia is, however, controversial, and large or long-term follow-up studies are not available. In a nationwide prospective follow-up study on very preterm and (or) very low birth weight infants (n = 717), we studied the relationship between thyroxine levels in the 1st wk of life and neurodevelopmental outcome at 5 y of age and school performance at 9 y of age. Thyroxine concentrations from filter paper eluates were determined in 717 infants: 32% had levels of more than 3 SD below the mean (<60 nmol/L). The percentage of infants with such low levels increased with decreasing gestational age. At the age of 5 y, 96% of survivors (n = 640) were available for extensive neurodevelopmental examination: 85 (13.3%) had a disability and 92 (14.3%) a handicap. At the age of 9 y, 83% of survivors (n = 552) answered a questionnaire on school performance: 300 (54.3%) were in mainstream education in a grade appropriate for age, 151 (27%) were in mainstream education with grade retention, and 101 (18.3%) were in special education. Both neurologic dysfunction at age 5 y and school failure at age 9 y were significantly related to lower neonatal thyroxine levels even after adjustment for other perinatal factors (odds ratio, 1.3) Whether this relationship is causal should be investigated. If a causal relationship exists, substitution therapy may at least partially prevent neurologic dysfunction and learning disabilities, both common sequelae of very preterm birth. Subject HealthThyrotropinClinical featureClinical trialCohort analysisFollow upLanguage developmentMajor clinical studyMental developmentNervous system developmentNeurologic diseaseNeurologic examinationPrematurityPriority journalProspective studyScreening testSpeechThyroxine blood levelVery low birth weightBirth WeightChildChild, PreschoolCohort StudiesFollow-Up StudiesGestational AgeHumansInfant, NewbornInfant, PrematureProspective StudiesThyroxine To reference this document use: http://resolver.tudelft.nl/uuid:8a02547d-bff0-45a4-8cd0-20198f391228 TNO identifier 233154 ISSN 0031-3998 Source Pediatric Research, 39 (1), 142-145 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.