Title
The human gastrointestinal microbiota - An unexplored frontier for pharmaceutical discovery
Author
Roeselers, G.
Bouwman, J.
Venema, K.
Montijn, R.
Publication year
2012
Abstract
The mammalian gastrointestinal tract (GIT) harbors microorganisms (the microbiota) of vast phylogentic, genomic, and metabolic diversity, and recent years have seen a rapid development in the techniques for studying these complex microbial ecosystems. It is increasingly apparent that the GIT microbiota plays an intricate role in host health and disease. Targeted strategies for modulating human health through the modification of the GIT microbiota, however, are developing and in their infancy. This perspective article discusses the rationale, benefits and limitations of using the GIT microbiota as a pharmacological and nutritional target in the treatment of various diseases and disorders linked to imbalances in our microbiota. © 2012 Elsevier Ltd.
Subject
Life
MSB - Microbiology and Systems Biology PHS - Pharmacokinetics & Human Studies
EELS - Earth, Environmental and Life Sciences
Food and Nutrition
Biology
Healthy Living
Drugs
Gut
Human microbiome
Metagenomics
Microbial ecology
To reference this document use:
http://resolver.tudelft.nl/uuid:8942c52b-d514-4919-bd09-ad505a30cb03
DOI
https://doi.org/10.1016/j.phrs.2012.09.007
TNO identifier
466434
ISSN
1043-6618
Source
Pharmacological Research, 66 (6), 443-447
Document type
article