Title
Automated synthesis of [18F]gefitinib on a modular system
Author
Läppchen, T.
Vlaming, M.L.H.
Custers, E.
Lub, J.
Sio, C.F.
DeGroot, J.
Steinbach, O.C.
Publication year
2012
Abstract
In recent years, [ 18F]gefitinib PET has successfully been employed for a number of applications ranging from oncology to in vivo studies of drug transporter proteins. We here report a reliable, automated procedure for routine synthesis of this radiotracer on an Eckert and Ziegler modular system. The 3-step radiosynthesis followed by preparative HPLC-purification provided [ 18F]gefitinib in 17.2±3.3% (n=22) overall decay-corrected radiochemical yield with radiochemical purity >99% in a total synthesis time of about 2.5h. © 2011 Elsevier Ltd.
Subject
Life
PHS - Pharmacokinetics & Human Studies
EELS - Earth, Environmental and Life Sciences
Biology
Healthy Living
Automated synthesis
Imaging of drug transporters
Modular system
PET tracer
Automated procedures
Automated synthesis
Gefitinib
In-vivo
Modular system
PET tracer
Radiochemical purity
Radiochemical yield
Radiosynthesis
Total synthesis
Transporter proteins
Automation
Biosynthesis
gefitinib f 18
radiopharmaceutical agent
unclassified drug
analytic method
article
automation
drug purification
drug structure
drug synthesis
high performance liquid chromatography
priority journal
quality control
radiochemistry
radioisotope decay
To reference this document use:
http://resolver.tudelft.nl/uuid:8586915a-c640-4a00-b4cd-69423b326c98
DOI
https://doi.org/10.1016/j.apradiso.2011.09.005
TNO identifier
446406
ISSN
0969-8043
Source
Applied Radiation and Isotopes, 70 (1), 205-209
Document type
article