Title
Consumption of reduced-fat products, haemostatic parameters and oral glucose tolerance test
Author
te Velthuis - Wierik, E.J.M.
Kluft, C.
van den Berg, H.
Weststrate, J.A.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1996
Abstract
A high fat intake has been associated with the high prevalence of coronary heart disease (CHD) in most Western countries. Consumption of reduced-fat products might reduce fat intake and beneficially affect markers of CHD risk. Therefore, the effects of 6 months of realistic consumption of reduced-fat products on energy and fat intake, concentrations of Factor VII, PAI-1 antigen and fibrinogen as well as t-PA activity were investigated. In addition, an oral glucose tolerance test was performed to study the effects on insulin sensitivity, in relation to haemostatic factors. Participants (n=76) were healthy, non-obese men and women. The reduced-fat group (n=40) had a significantly lower energy intake as well as a lower percentage of energy derived from fat than the control group (n=36), who received the full- fat equivalents. However, this did not result in differences in the haemostatic parameters measured, or in altered insulin sensitivity. It is concluded that consumption of reduced-fat products does not decrease, nor increase, CHD risk through improvement of the risk markers Factor VII, fibrinogen, PAI-1 antigen, t-PA activity and insulin sensitivity in healthy non-obese subjects.
Subject
Biology
blood clotting factor 7
fatty acid
fibrinogen
glucose
insulin
plasminogen activator inhibitor 1
tissue plasminogen activator
adult
article
controlled study
coronary artery disease
coronary risk
dietary intake
fat intake
female
fibrinolysis
glucose blood level
hematological parameters
hemostasis
human
insulin blood level
insulin sensitivity
major clinical study
male
oral glucose tolerance test
prevalence
priority journal
To reference this document use:
http://resolver.tudelft.nl/uuid:854c3b88-7eca-401f-a738-d071bd05e94d
DOI
https://doi.org/10.1016/s0268-9499(96)80027-0
TNO identifier
233420
ISSN
0268-9499
Source
Fibrinolysis, 10 (3), 159-166
Document type
article