Print Email Facebook Twitter Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes Title Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes Author Sillanaukee, P. van der Gaag, M.S. Sierksma, A. Hendriks, H.F.J. Strid, N. Pönniö, M. Nikkari, S.T. Publication year 2003 Abstract Background: There are only limited data obtained under well controlled conditions on the effects of moderate drinking on markers of alcohol use disorders. The aim of this study was to investigate the effects of moderate intake of different alcoholic beverages on these markers, including carbohydrate-deficient transferrin (CDT), sialic acid (SA), and the liver enzymes γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase. Methods: Eleven apparently healthy, nonsmoking middle-aged men were included in a 12-week randomized, diet-controlled crossover trial according to a 4 x 4 Latin-square design. Changes in CDT, SA, γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase were analyzed after 3 weeks of daily intake of four glasses (40 g of alcohol) of red wine, beer, spirits (Dutch gin), or water (control). Results: After 3 weeks' daily consumption of red wine, a significant decrease of serum CDT concentration was observed compared with water consumption. There was no effect of any alcoholic beverage on the other outcome measures. Conclusions: Daily consumption of 40 g of alcohol from different types of alcoholic beverages with dinner did not affect SA or liver enzymes. Further investigations to explore the mechanisms for the red wine-induced decreases of CDT, including changes in iron metabolism, are clearly needed. Subject HealthPhysiological SciencesAlcoholic BeveragesMarkers of Alcohol Use DisordersModerate Drinkingalanine aminotransferasealcoholaspartate aminotransferasecarbohydrate deficient transferringamma glutamyltransferaseliver enzymesialic acidwateradultalcohol consumptionalcoholic beveragealcoholismarticlebeerclinical trialcontrolled clinical trialcontrolled studycrossover proceduredisease markerdrinking behaviorenzyme blood levelginhumaniron metabolismmalemealnormal humanpriority journalrandomized controlled trialwineAdultAlanine TransaminaseAlcoholic BeveragesAnalysis of VarianceAspartate AminotransferasesBeerBiological Markersgamma-GlutamyltransferaseHumansLiverMaleMiddle AgedN-Acetylneuraminic AcidTransferrinWine To reference this document use: http://resolver.tudelft.nl/uuid:853c3122-1437-459b-812d-6dbc23463ce8 TNO identifier 236913 ISSN 0145-6008 Source Alcoholism: Clinical and Experimental Research, 27 (1), 57-60 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.