Title
Simultaneous identification of multiple β-lactamases in Acinetobacter baumannii in relation to carbapenem and ceftazidime resistance, using liquid chromatography-tandem mass spectrometry
Author
Trip, H.
Mende, K.
Majchrzykiewicz-Koehorst, J.A.
Sedee, N.J.A.
Hulst, A.G.
Jansen, H.J.
Murray, C.K.
Paauw, A.
Publication year
2015
Abstract
Shotgun proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied to detect β-lactamases in clinical Acinetobacter baumannii isolates. The correlation of the detection of β-lactamase proteins (rather than PCR detection of the corresponding genes) with the resistance phenotypes demonstrated an added value for LC-MS/MS in antimicrobial susceptibility testing. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Subject
Observation, Weapon & Protection Systems
CBRN - CBRN Protection
TS - Technical Sciences
Biology
Acinetobacter baumannii
To reference this document use:
http://resolver.tudelft.nl/uuid:84db6323-c982-484f-a068-0fa6fc8212c6
DOI
https://doi.org/10.1128/jcm.00620-15
TNO identifier
525581
Publisher
American Society for Microbiology
ISSN
0095-1137
Source
Journal of Clinical Microbiology, 53 (6), 1927-1930
Document type
article