Title
The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids
Author
Fluitman, K.S.
de Clercq, N.C.
Keijser, B.J.F.
Visser, M.
Nieuwdorp, M.
Ijzerman, R.G.
Publication year
2017
Abstract
Introduction: Malnutrition refers to both over- and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it harbors traits that complement the human metabolic and endocrine capabilities, thereby influencing energy balance. Areas covered: In the current review, we aim to give a comprehensive overview on the microbiota, its development and its possible influence on energy balance, with emphasis the role of short-chain fatty acids. We also consider microbial characteristics associated with obesity and undernutrition and evaluate microbial manipulating strategies. The PubMed database was searched using the terms: ‘gastrointestinal microbiota’, ‘volatile fatty acids’, ‘malnutrition’, ‘undernutrition’, ‘obesity’, ‘insulin resistance’, ‘prebiotics’, ‘probiotics’, ‘antibiotics’ and ‘fecal microbiota transplantation’. Expert commentary: Microbiota make important contributions to the regulation of energy balance, whereas microbial disturbances might predispose to malnutrition. If we manage to manipulate the microbiota to our benefit, it could lead to preventive or therapeutic strategies targeting malnutrition. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Biomedical Innovation
Energy balance
Fecal microbiota transplantation
Malnutrition
Microbiota
Prebiotics
Probiotics
Short-chain fatty acids
MSB - Microbiology and Systems Biology
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http://resolver.tudelft.nl/uuid:814c9417-afb5-4e3b-a770-73d6c53a24ed
DOI
https://doi.org/10.1080/17446651.2017.1318060
TNO identifier
762778
ISSN
1744-6651
Source
Expert Review of Endocrinology and Metabolism, 12 (12), 215-226
Document type
article