Title
Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB).
Author
van Triel, J.J.
Arts, J.H.
Muijser, H.
Kuper, C.F.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Previously, the contact allergen dinitrochlorobenzene (DNCB) was identified as a sensitizer by inhalation in BALB/c mice; in addition, DNCB induced a lymphocytic infiltrate in the larynx of dermally sensitized Th1-prone Wistar rats upon a single inhalation challenge. In the present study, repeated inhalation exposures to DNCB were investigated using the same protocol as the single-challenge study: female Wistar rats were dermally sensitized with DNCB and subsequently challenged by inhalation exposure to 7 or 15 mg/m(3) DNCB twice a week for 4 weeks. Allergy-related apnoeic breathing was not observed. DNCB-specific IgG antibodies were found in the serum and--predominantly lymphocytic--inflammations were found in the nasal tissues and larynx. Similar effects were observed in animals repeatedly exposed by inhalation without previous dermal contact, indicating sensitization by inhalation. The inflammation may be the upper respiratory tract analogue of hypersensitivity pneumonitis/allergic alveolitis. Possible progression of the airway inflammation upon long-term exposure should be investigated to support or dismiss discrimination between contact and respiratory allergens in relation to respiratory allergy. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Subject
Chemistry
1 chloro 2,4 dinitrobenzene
allergen
autacoid
animal
article
breathing mechanics
comparative study
drug effect
exposure
female
immunology
inhalational drug administration
pathology
pathophysiology
rat
respiratory system
skin allergy
Wistar rat
Administration, Inhalation
Allergens
Animals
Dermatitis, Allergic Contact
Dinitrochlorobenzene
Female
Inflammation Mediators
Inhalation Exposure
Rats
Rats, Wistar
Respiratory Mechanics
Respiratory System
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TNO identifier
346422
ISSN
1879-3185
Source
Toxicology, 269 (1), 73-80
Document type
article