Print Email Facebook Twitter No association between transient hypothyroxinaemia of prematurity and neurodevelopmental outcome in young adulthood Title No association between transient hypothyroxinaemia of prematurity and neurodevelopmental outcome in young adulthood Author Hollanders, J.J. Israëls, J. van der Pal, S.M. Verkerk, P.H. Rotteveel, J. Finken, M.J.J. Hille, E.T.M. de Groot, C.H. Kloosterboer-Boerrigter, H. den Ouden, A.L. Rijpstra, A. Verloove-Vanhorick, S.P. Vogelaar, J.A. Kok, J.H. Ilsen, A. van der Lans, M. Boelen-Van Der Loo, W.J.C. Lundqvist, T. Heymans, H.S.A. Duiverman, E.J. Geven, W.B. Duiverman, M.L. Geven, L.I. Vrijlandt, E.J.L.E. Mulder, A.L.M. Gerver, A. Kollée, L.A.A. Reijmers, L. Sonnemans, R. Wit, J.M. Dekker, F.W. Weisglas-Kuperus, N. van der Heijden, A.J. van Goudoever, J.B. van Weissenbruch, M.M. Cranendonk, A. Delemarre-Van De Waal, H.A. de Groot, L. Samsom, J.F. de Vries, L.S. Rademaker, K.J. Moerman, E. Voogsgeerd, M. de Kleine, M.J.K. Andriessen, P. Dielissen-Van Helvoirt, C.C.M. Mohamed, I. van Straaten, H.L.M. Baerts, W. Veneklaas Slots-Kloosterboer, G.W. Tuller-Pikkemaat, E.M.J. Ens-Dokkum, M.H. van Steenbrugge, G.J. Publication year 2015 Abstract Context: Transient hypothyroxinaemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective: To examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-for-gestational-age birth (POPS) cohort, which included infants born very preterm (i.e., <32 weeks) and/or with a very low birth weight (i.e., <1,500 g). Setting: Multicenter study Patients: 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: Thyroxine (T4) concentrations were obtained through the national neonatal screening program for congenital hypothyroidism. THoP was defined as a total T4 concentration <-3 SD of the daily mean (approximately 60 nmol/L). Main outcome measures: IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen’s examination of minor neurologic dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference: 0 (95% confidence interval: -3.8 to 3.8) points) or motor function (mean difference: 0.6 (95% confidence interval: -1.3 to 2.5) points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found. Subject LifeCH - Child HealthELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy Living To reference this document use: http://resolver.tudelft.nl/uuid:80f64c7b-8ffe-42b1-93ae-eb9082cd3494 DOI https://doi.org/10.1210/jc.2015-3078 TNO identifier 528867 Source Journal of Clinical Endocrinology & Metabolism, 100 (12), 4648-4653 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.