Title
Embryotoxicity and teratogenicity study with erythritol in rats
Author
van Smits- Prooije, A.E.
Waalkens-Berendsen, D.H.
Bär, A.
Publication year
1996
Abstract
The embryotoxicity/teratogenicity of erythritol, a low-calorie polyol sugar substitute, was examined in Wistar Crl:(WI) WU BR rats. Erythritol was fed at dietary concentrations of 0, 2.5, 5, and 10% to groups of 32 female rats from Day 0 to 21 of gestation. The treatment was generally well tolerated and no mortality occurred in any group. Weight gain during gestation, food consumption, and food efficiency were similar in all groups except for a significantly reduced weight gain in the 10% erythritol group in Week 2 of gestation. Reproductive performance was not affected by the treatment but the fertility index was generally rather low (69% in both control and high-dose group). Examination of the fetuses for external, visceral, and skeletal alterations did not reveal any fetotoxic, embryotoxic, or teratogenic effects. The slightly lower maternal body weight in the high-dose group was interpreted as a trivial result of the consumption of a low-calorie test substance in high amounts. In conclusion, no adverse effects were observed at erythritol doses of up to about 6.6 g/kg body wt/day, i.e., the highest dose tested.
Subject
erythritol
animal experiment
animal model
article
embryo
embryotoxicity
female
fetotoxicity
fetus
male
nonhuman
priority journal
rat
teratogenicity
Abnormalities, Drug-Induced
Animals
Body Weight
Diet
Embryo
Erythritol
Female
Fertility
Male
Pregnancy
Rats
Rats, Wistar
Sweetening Agents
Teratogens
Animalia
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DOI
https://doi.org/10.1006/rtph.1996.0103
TNO identifier
233711
ISSN
0273-2300
Source
Regulatory Toxicology and Pharmacology, 24 (2 II)
Document type
article