Print Email Facebook Twitter Intake of fruits and vegetables and risk of pancreatic cancer in a pooled analysis of 14 Cohort studies Title Intake of fruits and vegetables and risk of pancreatic cancer in a pooled analysis of 14 Cohort studies Author Koushik, A. Spiegelman, D. Albanes, D. Anderson, K.E. Bernstein, L. van den Brandt, P.A. Bergkvist, L. English, D.R. Freudenheim, J.L. Fuchs, C.S. Genkinger, J.M. Giles, G.G. Goldbohm, R.A. Horn-Ross, P.L. Männistö, S. McCullough, M.L. Millen, A.E. Miller, A.B. Robien, K. Rohan, T.E. Schatzkin, A. Shikany, J.M. Stolzenberg-Solomon, R.Z. Willett, W.C. Wolk, A. Ziegler, R.G. Smith-Warner, S.A. Publication year 2012 Abstract Fruit and vegetable intake may protect against pancreatic cancer, since fruits and vegetables are rich in potentially cancer-preventive nutrients. Most case-control studies have found inverse associations between fruit and vegetable intake and pancreatic cancer risk, although bias due to reporting error cannot be ruled out. In most prospective studies, inverse associations have been weaker and imprecise because of small numbers of cases. The authors examined fruit and vegetable intake in relation to pancreatic cancer risk in a pooled analysis of 14 prospective studies from North America, Europe, and Australia (study periods between 1980 and 2005). Relative risks and 2-sided 95 confidence intervals were estimated separately for the 14 studies using the Cox proportional hazards model and were then pooled using a random-effects model. Of 862,584 men and women followed for 7-20 years, 2,212 developed pancreatic cancer. The pooled multivariate relative risks of pancreatic cancer per 100-g/day increase in intake were 1.01 (95 confidence interval (CI): 0.99, 1.03) for total fruits and vegetables, 1.01 (95 CI: 0.99, 1.03) for total fruits, and 1.02 (95 CI: 0.99, 1.06) for total vegetables. Associations were similar for men and women separately and across studies. These results suggest that fruit and vegetable intake during adulthood is not associated with a reduced pancreatic cancer risk. © 2012 The Author. Subject HumanLS - Life StyleBSS - Behavioural and Societal SciencesHealthy for LifeHealthHealthy Livingdietfruitpancreatic neoplasmsprospective studiesvegetables To reference this document use: http://resolver.tudelft.nl/uuid:7df74407-5a79-4ba4-a71f-601a97c1cf6e DOI https://doi.org/10.1093/aje/kws027 TNO identifier 464279 ISSN 0002-9262 Source American Journal of Epidemiology, 176 (5), 373-386 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.