Print Email Facebook Twitter Activated protein C response and cardiovascular risk factors in the elderly - The Rotterdam Study Title Activated protein C response and cardiovascular risk factors in the elderly - The Rotterdam Study Author Bots, M.L. van der Bom, J.G. Haverkate, F. Meijer, P. Hofman, A. Grobbee, D.E. Kluft, C. TNO Preventie en Gezondheid Publication year 1996 Abstract Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately controlled for as possible confounders. We studied the association of APC response to cardiovascular risk factors in a sample of the general population. Methods. The Rotterdam Study is a cohort study among 7983 subjects aged 55 years or over, living in the Ommoord suburb in Rotterdam, The Netherlands. APC response was measured in 928 subjects as part of two case-control studies (subjects with and without symptomatic cardiovascular disease (CVD) and with and without dementia). APC response was determined in double centrifuged platelet poor plasma. Those on anticoagulants were excluded. Linear regression analyses were done in age strata (55-64, 65-74, 75-84, ≤ 85), with adjustment for age, sex, CVD, and dementia. Results. APC response was lower in women than in men (difference 0.56 (p < 0.01)). In men, APC response decreased with age (0.15 per decade (p = 0.02)). In women, a non-significant rise was seen (0.05 per decade (p = 0.27)). Associations with cardiovascular risk factors differed by age, not gender. In those aged 55-64 years inverse associations were found with total cholesterol (0.14 decrease per 1 mmol/l increase, p = 0.08) and diastolic pressure (0.12 decrease per 10 mmHg increase, p = 0.06). In those aged ≤ 85 years a positive association was seen with smoking (0.76 increase, p = 0.01). No associations were found with systolic pressure and body mass index. Conclusion. These findings suggest that in the elderly age, gender, serum lipids, diastolic pressure and smoking may influence APC response, the extent of which may differ by age. These factors should be allowed for in studies on the association between APC response and arterial disease. Subject HealthActivated protein cAdultAgedCardiovascular diseaseCohort analysisConference paperControlled studyFemaleHumanMajor clinical studyMaleRisk factor To reference this document use: http://resolver.tudelft.nl/uuid:7b4fa3e9-553f-4872-955d-ee70e3ccd806 DOI https://doi.org/10.1016/s0268-9499(96)80077-4 TNO identifier 233507 ISSN 0268-9499 Source Fibrinolysis, 10 (SUPPL. 2), 161-164 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.