Title
Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials = Développer des références régionales de croissance pour le rapport poids/âge dans les pays où le paludisme est endémique, afin d’optimiser la posologie des médicaments antipaludiques en fonction de l’âge = Elaboración de referencias regionales sobre el crecimiento ponderal correspondiente a cada edad para los países donde la malaria es endémica a fin de optimizar la dosificación basada en la edad de los medicamentos contra la malaria
Author
Hayes, D.J.
van Buuren, S.
ter Kuile, F.O.
Stasinopoulos, D.M.
Rigby, R.A.
Terlouw, D.J.
Publication year
2015
Abstract
Methods: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than 50 years in 64 malaria-endemic countries. Regional growth references were generated using a generalized additive model for location, scale and shape by combining data with varying distributions from a range of sources. Countries were weighted by their population at risk of malaria to enable references to be used in optimizing the dosing of antimalarials. Findings: Large differences in weight-for-age distributions existed between the regions and between the regions and global growth standards. For example, the average adult male from the Americas weighed 68.1 kg – 6.0 kg more than males in South-East Asia and the Western Pacific (average: 62.1 kg). For adult women, the difference was over 10.4 kg: the average was 60.4 kg in the Americas and 50.0 kg in South-East Asia and the Western Pacific. Conclusion: There were substantial variations in weight-for-age growth curves between malaria-endemic areas. The growth reference charts derived here can be used to guide the evidence-based optimization of aged-based dosing regimens for antimalarials and other drugs often prescribed by age. Objective: To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific.
Subject
Life
LS - Life Style
ELSS - Earth, Life and Social Sciences
Healthy for Life
Healthy Living
Antimalarial agent
Antimalarial agent
Database
Endemic species
Health risk
Malaria
Optimization
Public health
Weight
Adolescent
Adult
Age distribution
Body weight
Child
Controlled study
Endemic disease
Female
Growth curve
Health survey
Human
Infant
Infection risk
Male
Newborn
Plasmodium falciparum
Plasmodium vivax
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http://resolver.tudelft.nl/uuid:7b4f1fe2-fc81-4c43-afa3-71ff0be51b41
DOI
https://doi.org/10.2471/blt.14.139113
TNO identifier
523202
ISSN
0042-9686
Source
Bulletin of the World Health Organization, 93 (2), 74-83
Document type
article