Print Email Facebook Twitter Quality and safety of Chinese herbal medicines guided by a systems biology perspective Title Quality and safety of Chinese herbal medicines guided by a systems biology perspective Author Wang, J. van der Heijden, R. Spruit, S. Hankermeier, T. Chan, K. van der Greef, J. Xu, G. Wang, M. TNO Kwaliteit van Leven Publication year 2009 Abstract Chinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparations at the different steps of production; harvesting, processing and the final formulation. The historic perspective and today's issues of the safety of CMM are introduced briefly, followed by the descriptions of the toxic CMM in the current Chinese Pharmacopoeia (2005). Subsequently, several aspects of safety are illustrated using a typical example of a toxic CMM, Aconitum roots, and some recent findings of our own research are included to illustrate that proper processing and multi-herbs formulation can reduce the level of toxic components. This also explains that in CMM, some herbs, such as Aconitum, Ephedra species are never used as single herb for intervention and that aconite is only used when it is processed and in combination with specific matched other herbs. The formulation principle of multi-herbs intervention strategy is a systems approach for the treatment and prevention of disease. In this light, the role of systems toxicology in the safety and quality of Chinese herbal medicine is proposed as a promising method. Moreover the principles of practiced-based and evidence-based research are discussed from a symbiotic perspective. © 2009 Elsevier Ireland Ltd. All rights reserved. Subject Health PharmacologyPhysiological SciencesAconitum rootsChinese materia medicaMetabolomicsSystems biologySystems toxicology To reference this document use: http://resolver.tudelft.nl/uuid:7b3c9332-d1b3-45df-b946-a80f4f78e172 DOI https://doi.org/10.1016/j.jep.2009.07.040 TNO identifier 242130 ISSN 0378-8741 Source Journal of Ethnopharmacology, 126 (1), 31-41 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.