Title
Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response
Author
Maassen, C.B.M.
van Holten, J.C.A.M.
Balk, F.
Heijne den Bak-Glashouwer, M.J.
Leer, R.
Laman, J.D.
Boersma, W.J.A.
Claassen, E.
TNO Preventie en Gezondheid
Publication year
1998
Abstract
In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune encephalomyelitis (EAE). Immuno- histochemical analysis of cytokine profiles showed that differential modulation is obtained dependent on the Lactobacillus strain applied. Serum antibody responses to i.p. immunisation with chicken gama globulin in BALB/c mice are also modulated by oral application of Lactobacillus. Lactobacilli are now being developed as safe live antigen carriers for application in vaccine technology, but also for the excretion of autoantigens in order to induce tolerance. The findings of this study imply that by proper strain selection the direction of the response can be influenced by the induction of a specific cytokine profile.
Subject
Nutrition
lactobacillus vaccine
allergic encephalomyelitis
animal model
antibody blood level
conference paper
cytokine production
immune response
immunization
immunohistochemistry
lactobacillus
nonhuman
rat
Adjuvants, Immunologic
Administration, Oral
Animals
Antibody Formation
Cytokines
Encephalomyelitis, Autoimmune, Experimental
Female
gamma-Globulins
Intestine, Small
Lactobacillus
Mice
Mice, Inbred BALB C
Picrates
Probiotics
Cytokines
gamma-Globulins
Picrates
picric acid, 88-89-1
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TNO identifier
70956
Source
The Veterinary Quarterly, 20 (suppl. 3), p. S81-S83
Document type
article