Title
Lack of effect of doxycycline on disease activity and joint damage in patients with rheumatoid arthritis. A double blind, placebo controlled trial
Author
van der Laan, W.
Molenaar, E.
Ronday, K.
Verheijen, J.
Breedveld, F.
Greenwald, R.
Dijkmans, B.
Tekoppele, J.
Gaubius instituut TNO
Publication year
2001
Abstract
Objective. To investigate the effects of doxycycline on disease activity and joint destruction in patients with rheumatoid arthritis (RA). Methods. A 36 week double blind, placebo controlled crossover trial was conducted. Patients (n = 66) received 50 mg doxycycline or placebo twice a day during 12, 24, or 36 weeks. Patient assessments were performed before the treatment was administered, at 6, 12, 24 and 36 weeks of treatment, and finally at 4 weeks after cessation of treatment. Patient assessments, swollen and tender joint counts, duration of morning stiffness, erythrocyte sedimentation rate, and Modified Disease Activity Score were used as measures of disease activity. Effects on joint destruction were assessed by urinary excretion of the pyridinolines hydroxylysylpyridinoline and lysylpyridinoline and by scoring radiographic damage of hands and feet before and after treatment. Results. The changes of clinical or laboratory disease activity measures, pyridinoline excretion, or progression of radiographic joint damage during doxycycline or placebo treatment did not differ significantly. Conclusion. The results indicate that 50 mg doxycycline twice a day provided no therapeutic benefit for patients with RA.
Subject
Health
Biomedical Research
Doxycycline
Pyridinolines
Rheumatoid arthritis
deoxypyridinoline
doxycycline
placebo
pyridinoline
clinical examination
clinical trial
controlled clinical trial
controlled study
crossover procedure
disease activity
double blind procedure
erythrocyte sedimentation rate
foot radiography
hand radiography
joint destruction
joint stiffness
laboratory test
major clinical study
randomized controlled trial
scoring system
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Arthritis, Rheumatoid
Chi-Square Distribution
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Doxycycline
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Middle Aged
Pain Measurement
Reference Values
Severity of Illness Index
Treatment Failure
Treatment Outcome
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TNO identifier
236218
ISSN
0315-162X
Source
Journal of Rheumatology, 28 (9), 1967-1974
Document type
article