Title
Pulmonary response of hamsters to fibrous glass: Chronic effects of repeated intratracheal instillation with or without benzo[a]pyrene
Author
Feron, V.J.
Scherrenberg, P.M.
Immel, H.R.
Spit, B.J.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1985
Abstract
Syrian golden hamsters were given intratracheal instillations of glass fibres with or without benzo[a]pyrene suspended in saline, once a fortnight for 52 weeks. The experiment was terminated at week 85. 'Silicotic granulomas' consisting of tightly packed, iron-positive macrophages filled with glass fibres and surrounded by a layer of alveolar epithelial cells were the predominant pulmonary lesion. No mesotheliomas or other tumours of the respiratory tract were observed in hamsters treated with glass fibres alone. There was no indication that glass fibres enhanced the development of respiratory tract tumours induced by benzo[a]pyrene. In hamsters similarly exposed to crocidolite fibres with or without benzo[a]pyrene no mesotheliomas or other respiratory tract tumours were observed either. An explanation for the absence of pulmonary tumours might be that repeated administration of fibres over a period of 52 weeks entails an acute pulmonary reaction after each administration with the implication that the fibres cannot settle down well enough to be able to induce tumours. Another possible explanation is the relatively short duration of the experimental period. Chemicals/CAS: benzo[a]pyrene, 50-32-8; crocidolite, 12001-28-4, 53799-46-5, 61105-31-5; Asbestos, 1332-21-4; Benzo(a)pyrene, 50-32-8; Glass
Subject
Benzo[a]pyrene
Crocidolite
Glass fiber
Animal experiment
Animal model
Biological model
Endotracheal intubation
Hamster
Histology
Histopathology
Lung
Lung fibrosis
Nonhuman
Pneumoconiosis
Respiratory system
Therapy
Animal
Asbestos
Benzo(a)pyrene
Glass
Granuloma
Hamsters
Lung
Male
Mesocricetus
Silicosis
Support, Non-U.S. Gov't
Time Factors
To reference this document use:
http://resolver.tudelft.nl/uuid:7a8f454c-1998-4e01-978e-18ab050cb319
TNO identifier
230004
ISSN
0143-3334
Source
Carcinogenesis, 6 (10), 1495-1499
Document type
article