Print Email Facebook Twitter Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection Title Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection Author van Putten, L.M. Kram, L.K.J. van Dierendonck, H.H.C. Radiobiologisch Instituut TNO Publication year 1975 Abstract In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and of Corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. This finding confirms the observation of others that major modification of the resistance to metastatic tumour formation can occur independently of classical immunological mechanisms. Special attention is drawn to the fact that cyclophosphamide enhances the formation of metastatic nodules in this model by factors of 100 to more than 1,000, whereas other cytostatic drugs include the cyclophosphamide congeners iphosphamide and trophosphamide are active only by factors between 2 and 12. The possible practical significance of these findings is discussed. Chemicals/CAS: cyclophosphamide, 50-18-0; ifosfamide, 3778-73-2; trofosfamide, 22089-22-1; Alkylating Agents; Antineoplastic Agents; Busulfan, 55-98-1; Globulins; Mitolactol, 10318-26-0; Nitrogen Mustard Compounds Subject cyclophosphamideifosfamidetrofosfamidebacterium clearancecancercancer cellcancer chemotherapycancer immunologycancer resistancecancer susceptibilitycell transplantationcorynebacterium parvumlung metastasismetastasisosteosarcomaradiationAlkylating AgentsAnimalAntineoplastic AgentsBusulfanCell Transformation, NeoplasticGlobulinsHorsesImmunosuppressionLungLung NeoplasmsLymph NodesMaleMiceMice, Inbred StrainsMitolactolNeoplasm MetastasisNeoplasm TransplantationNitrogen Mustard CompoundsOsteosarcomaPropionibacterium acnesRadiation EffectsSarcoma, ExperimentalSupport, U.S. Gov't, P.H.S. To reference this document use: http://resolver.tudelft.nl/uuid:79062ce3-3a45-4030-a706-980f5408509a TNO identifier 227852 ISSN 0020-7136 Source International Journal of Cancer, 15 (4), 588-595 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.