Print Email Facebook Twitter Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study Title Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study Author Stroeve, J.H.M. Saccenti, E. Bouwman, J. Dane, A. Strassburg, K. Vervoort, J. Hankemeier, T. Astrup, A. Smilde, A.K. van Ommen, B. Saris, W.H.M. Publication year 2016 Abstract Objective: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. Methods: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low calorie diet (800 kcal) for 8-weeks. Men (N5236) and women (N5431) as well as groups with overweight/obesity and morbid obesity were studied separately. The relation between the metabolic status before weight loss and weight loss was assessed by stepwise regression on multiple datasets, including anthropometric parameters, NMR-based plasma metabolites, and LC-MS-based plasma lipid species. Results: Maximally, 57% of the variation in weight loss success can be predicted by baseline parameters. The most powerful predictive models were obtained in subjects with morbid obesity. In these models, the metabolites most predictive for weight loss were acetoacetate, triacylglycerols, phosphatidylcholines, specific amino acids, and creatine and creatinine. This metabolic profile suggests that high energy metabolism activity results in higher amounts of weight loss. Conclusions: Possible predictive (pre-diet) markers were found for amount of weight loss for specific subgroups. Subject LifeMSB - Microbiology and Systems BiologyELSS - Earth, Life and Social SciencesFood and NutritionNutritionHealthy Living3 hydroxy 2 methylpropionic acid3 hydroxybutyric acidAcetic acidAcetoacetic acidAlanineCholesterolCreatineCreatinineFatty acidGlucoseGlycineHigh density lipoprotein cholesterolInsulinIsoleucineIsovaleric acidLactic acidLow density lipoprotein cholesterolPhosphatidylcholineProlineTriacylglycerolTyrosineValineAdultAmino acid blood levelAnalytical parametersCholesterol blood levelControlled studyCreatinine blood levelDiastolic blood pressureEnergy metabolismFatty acid blood levelFemaleGlucose blood levelHumanInsulin blood levelLiquid chromatographyLow calory dietMaleMass spectrometryMorbid obesityNuclear magnetic resonanceObesityPhospholipid blood levelProtein blood levelRandomized controlled trialSystolic blood pressureTriacylglycerol blood levelWaist circumferenceWeight reduction To reference this document use: http://resolver.tudelft.nl/uuid:78d3d9b8-f11b-4bf6-98fd-28c99151db2d DOI https://doi.org/10.1002/oby.21361 TNO identifier 530775 Source Obesity, 24 (2), 379-388 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.