Title
Comparison of growth, nitrogen metabolism and organ weights in piglets and rats fed on diets containing Phaseolus vulgaris beans
Author
Centraal Instituut voor Voedingsonderzoek TNO Instituut voor Landbouwkundig Onderzoek van Biochemische Produkten TNO
Huisman, J.
van der Poel, A.F.B.
van Leeuwen, P.
Verstegen, M.W.A.
Publication year
1990
Abstract
The effects of lectins in the diet have been mainly studied in rats. An important question is whether results obtained in rats can be extrapolated to larger animals like the pig. Phaseolus vulgaris beans are rich in toxic lectins. Therefore a study was carried out to compare the effects of diets containing 200 g Phaseolus vulgaris beans (raw or toasted)/kg in rats and piglets. Live-weight gain, nitrogen digestibility and N balance were much lower in piglets than in rats fed on diets containing raw beans. Live-weight gain and N balance were slightly negative in the piglets. When toasted beans were given, live-weight gain and N balance values were reduced in piglets but hardly at all in rats. Giving raw beans caused hypertrophy of the pancreas in the rats but in piglets the weight of the pancreas was reduced. Spleen weight was depressed in the piglets but not in the rats. Weight of liver was not affected in either animal species. When toasted beans were given no effects on the weights of pancreas, spleen or liver were found in piglets or rats. It was concluded that the piglet is much more sensitive to antinutritional factors in thge Phaseolus vulgaris bean than the rat.
Subject
Antinutritional factors
Lectins
Phaseolus vulgaris
Piglet
Animal experiment
Animal tissue
Controlled study
Male
Nitrogen balance
Nonhuman
Animal
Animal Feed
Body Weight
Comparative Study
Fabaceae
Liver
Nitrogen
Organ Weight
Pancreas
Phytohemagglutinins
Plants, Medicinal
Rats
Rats, Inbred Strains
Spleen
Swine
Trypsin Inhibitors
Animalia
Phaseolus (angiosperm)
Phaseolus vulgaris
Sus scrofa
To reference this document use:
http://resolver.tudelft.nl/uuid:781968fb-c825-477c-8436-e7e20e734292
DOI
https://doi.org/10.1079/bjn19900076
TNO identifier
231355
ISSN
0007-1145
Source
British Journal of Nutrition, 64 (64), 743-753
Document type
article