Print Email Facebook Twitter Periconceptional folic acid use and the prevalence of neural tube defects in The Netherlands Title Periconceptional folic acid use and the prevalence of neural tube defects in The Netherlands Author van der Pal-de Bruin, K.M. van der Heijden, P.G.M. Buitendijk, S.E. den Ouden, A.L. TNO Preventie en Gezondheid Publication year 2003 Abstract Objective: To study the effect of increased folic acid intake on the prevalence of neural tube defects (NTD) in The Netherlands. Study design: Using the capture-recapture method, the prevalence of NTD was estimated on the basis of five different registries on births affected by NTD. Results: Total prevalence over the 1988-1998 period varied between 1.43 and 1.96 per 1000 live and still births. No decrease in total prevalence was found to have taken place during that period. Scrutiny of the last 2 years, 1997 and 1998, in which increased folic acid intake might be expected to have had an effect, did not give any indication that the prevalence of NTD was falling. Conclusions: A decrease in the Dutch prevalence of NTD during the study period could not be demonstrated due to the relatively small number of women using folic acid periconceptionally. This does not mean automatically that periconceptional folic acid use is ineffective in reducing the Dutch prevalence of NTD. Further monitoring is needed. © 2002 Elsevier Science Ireland Ltd. All rights reserved. Subject HealthFolic acid usePrevalence NTDTrendDietary SupplementsFemaleFertilizationFolic AcidGestational AgeHumansInfant, NewbornNetherlandsNeural Tube DefectsPregnancyRegistries To reference this document use: http://resolver.tudelft.nl/uuid:77b68281-6983-4fd3-908e-aa80e8c9b208 DOI https://doi.org/10.1016/s0301-2115(02)00362-7 TNO identifier 237079 ISSN 0301-2115 Source European Journal of Obstetrics Gynecology and Reproductive Biology, 108 (1), 33-39 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.