Title
Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats
Author
Instituut CIVO-Toxicologie en Voeding TNO
Appel, M.J.
Meijers, M.
van Garderen-Hoetmer, A.
Lamers, C.B.H.W.
Rovati, L.C.
Sprij-Mooij, D.
Jansen, J.B.M.J.
Woutersen, R.A.
Publication year
1992
Abstract
The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment. Cholecystokinin, but not dietary unsaturated fat, increased pancreatic weight. Rats treated with cholecystokinin developed more acidophilic atypical acinar cell nodules, adenomas and adenocarcinomas than control animals. Rats maintained on the high-fat diet developed significantly more adenomas and adenocarcinomas than controls given a diet low in unsaturated fat. Lorglumide largely inhibited the enhancing effect of cholecystokinin, but not of dietary fat, on pancreatic carcinogenesis indicating that it is unlikely that the promoting effect of dietary unsaturated fat on pancreatic carcinogenesis is mediated via cholecystokinin. Chemicals/CAS: azaserine, 115-02-6; cholecystokinin, 9011-97-6, 93443-27-7; lorglumide, 97964-56-2; Azaserine, 115-02-6; Cholecystokinin, 9011-97-6; Dietary Fats; lorglumide, 97964-56-2; Proglumide, 6620-60-6; Receptors, Cholecystokinin
Subject
Zoology
Medicine
Geneeskunde
Pathology
Animal
Azaserine
Body Weight
Cholecystokinin
Dietary Fats
Liver
Male
Organ Weight
Pancreas
Pancreatic Neoplasms
Proglumide
Rats
Rats, Inbred Strains
Receptors, Cholecystokinin
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TNO identifier
64636
ISSN
0007-0920
Source
British Journal of Cancer, 66 (66), 46-50
Document type
article