Print Email Facebook Twitter Use of transgenic mice in lipoprotein metabolism and atherosclerosis research Title Use of transgenic mice in lipoprotein metabolism and atherosclerosis research Author Havekes, L.M. van Vlijmen, B.J.M. Jong, M.C. van Dijk, K.W. Hofker, M.H. Gaubius Instituut TNO Publication year 1997 Abstract In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride. Subject BiologyAge FactorsAnimalsApolipoprotein E3Apolipoproteins CApolipoproteins EArteriosclerosisCholesterolFemaleHumansLipidsLipoproteinsLipoproteins, VLDLMaleMiceMice, TransgenicSex FactorsAnimaliaMus musculus To reference this document use: http://resolver.tudelft.nl/uuid:7675a62c-1e3b-441b-bac0-73c67cf2828b TNO identifier 234073 ISSN 0952-3278 Source Prostaglandins Leukotrienes and Essential Fatty Acids, 57 (4-5), 463-466 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.