Title
Use of transgenic mice in lipoprotein metabolism and atherosclerosis research
Author
Havekes, L.M.
van Vlijmen, B.J.M.
Jong, M.C.
van Dijk, K.W.
Hofker, M.H.
Gaubius Instituut TNO
Publication year
1997
Abstract
In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.
Subject
Biology
Age Factors
Animals
Apolipoprotein E3
Apolipoproteins C
Apolipoproteins E
Arteriosclerosis
Cholesterol
Female
Humans
Lipids
Lipoproteins
Lipoproteins, VLDL
Male
Mice
Mice, Transgenic
Sex Factors
Animalia
Mus musculus
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http://resolver.tudelft.nl/uuid:7675a62c-1e3b-441b-bac0-73c67cf2828b
TNO identifier
234073
ISSN
0952-3278
Source
Prostaglandins Leukotrienes and Essential Fatty Acids, 57 (4-5), 463-466
Document type
article