Print Email Facebook Twitter Toll-like receptors as targets for inflammation, development and repair in the central nervous system Title Toll-like receptors as targets for inflammation, development and repair in the central nervous system Author van Noort, J.M. TNO Kwaliteit van Leven Publication year 2007 Abstract Toll-like receptors (TLRs) that play key roles in inflammation are also widely expressed in the CNS. While they are well known to activate inflammatory responses to microbial products, TLRs fulfill additional roles in the absence of infection. Emerging evidence suggests that several TLRs play a role in CNS development during fetal life and in repair during adult life. This review discusses the available data on the expression and function of individual TLR family members in the CNS and clarifies why TLRs deserve close scrutiny as a novel group of therapeutic targets for CNS disorders. © The Thomson Corporation. Subject Biomedical ResearchAstrocyteCNSInflammationMicrogliaTissue repairToll-like receptorAnimalsCentral Nervous SystemCentral Nervous System DiseasesHumansInflammationToll-Like Receptors To reference this document use: http://resolver.tudelft.nl/uuid:75a72215-d059-4c5f-9b2b-d4e40a2710d3 TNO identifier 239783 ISSN 1472-4472 Source Current Opinion in Investigational Drugs, 8 (1), 60-65 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.