Print Email Facebook Twitter Intelligence of very preterm or very low birthweight infants in young adulthood Title Intelligence of very preterm or very low birthweight infants in young adulthood Author Weisglas-Kuperus, N. Hille, E.T.M. Duivenvoorden, H.J. Finken, M.J.J. Wit, J.M. van Buuren, S. van Goudoever, J.B. Verloove-Vanhorick, S.P. TNO Kwaliteit van Leven Publication year 2009 Abstract Objective: To examine the effect of intrauterine and neonatal growth, prematurity and personal and environmental risk factors on intelligence in adulthood in survivors of the early neonatal intensive care era. Methods: A large geographically based cohort comprised 94% of all babies born alive in the Netherlands in 1983 with a gestational age below 32 weeks and/or a birth weight >1500 g (POPS study). Intelligence was assessed in 596 participants at 19 years of age. Intrauterine and neonatal growth were assessed at birth and 3 months of corrected age. Environmental and personal risk factors were maternal age, education of the parent, sex and origin. Results: The mean (SD) IQ of the cohort was 97.8 (15.6). In multiple regression analysis, participants with highly educated parents had a 14.2-point higher IQ than those with less well-educated parents. A 1 SD increase in birth weight was associated with a 2.6-point higher IQ, and a 1-week increase in gestational age was associated with a 1.3-point higher IQ. Participants born to young mothers (<25 years) had a 2.7-point lower IQ, and men had a 2.1-point higher IQ than women. The effect on intelligence after early (symmetric) intrauterine growth retardation was more pronounced than after later (asymmetric) intrauterine or neonatal growth retardation. These differences in mean IQ remained when participants with overt handicaps were excluded. Conclusions: Prematurity as well as the timing of growth retardation are important for later intelligence. Parental education, however, best predicted later intelligence in very preterm or very low birthweight infants. Subject HealthLeefomgeving en gezondheidCognitive defectDisabilityDisease severityEducationEnvironmental factorIntrauterine growth retardationParentPostnatal growthPrematurityPrenatal growthRisk assessmentSex differenceSurvival rateChild DevelopmentCohort StudiesEducational StatusFetal Growth RetardationGestational AgeHumansInfant, NewbornInfant, Very Low Birth WeightIntelligenceMaternal AgeNetherlandsRisk FactorsYoung Adult To reference this document use: http://resolver.tudelft.nl/uuid:758a2351-6893-47ee-88f5-c734395b152b DOI https://doi.org/10.1136/adc.2007.135095 TNO identifier 241506 ISSN 0003-9888 Source Archives of Disease in Childhood : Fetal and Neonatal Edition, 94 (3), F196-F200 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.