Title
Live bacterial delivery systems for development of mucosal vaccines
Author
Thole, J.E.R.
van Dalen, P.J.
Havenith, C.E.G.
Pouwels, P.H.
Seegers, J.F.M.L.
Tielen, F.D.
van der Zee, M.D.
Zegers, N.D.
Shaw, M.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2000
Abstract
By expression of foreign antigens in attenuated strains derived from bacterial pathogens and in non-pathogenic commensal bacteria, recombinant vaccines are being developed that aim to stimulate mucosal immunity. Recent advances in the pathogenesis and molecular biology of these bacteria have allowed rational development of new and improved bacterial carriers and more effective gene expression systems. These advances have improved the performance and versatility of these delivery systems to induce mucosal immunity to recombinant antigens in animal models. Application of these (improved) technologies for development of human vaccines is still limited and awaits further exploration Chemicals/CAS: BCG Vaccine; Vaccines, Attenuated; Vaccines, Synthetic
Subject
Nutrition
Attenuated bacteria
Commensal bacteria
Gene expression system
Mucosal immunity
Mucosal vaccines
Oral vaccines
Drug carrier
Recombinant vaccine
Vaccine
Antigen expression
Bacterium
Drug delivery system
Drug research
Gene expression system
Immune response
Lactic acid bacterium
Lactobacillus
Lactococcus lactis
Mucosa
Mycobacterium
Review
Salmonella
Staphylococcus carnosus
Streptococcus gordonii
Vibrio cholerae
Animals
Bacteria
BCG Vaccine
Drug Delivery Systems
Genetic Vectors
Humans
Immunity, Mucosal
Lactobacillus
Lactococcus lactis
Salmonella
Staphylococcus
Streptococcus
Vaccines, Attenuated
Vaccines, Synthetic
Vibrio cholerae
Animalia
Bacteria (microorganisms)
Lactobacillus mucosae
Lactococcus lactis
Mycobacterium
Salmonella
Staphylococcus carnosus
Streptococcus gordonii
Vibrio cholerae
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TNO identifier
88907
ISSN
1464-8431
Source
Current Opinion in Molecular Therapeutics, 2 (1), 94-99
Document type
article