Print Email Facebook Twitter Immune System Title Immune System Author Ruehl-Fehlert, C. Parker, G.A. Elmore, S.A. Kuper, C.F. Contributor Wallig, M. (editor) Bolon, B. (editor) Haschek, W.M. (editor) Rousseaux, C. (editor) Publication year 2017 Abstract Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased susceptibility to infections and in the development of tumors. Toxicity may also be caused via the generation of a specific immune response against the compound or by deregulation of immunological responses, leading to allergy/hypersensitivity or autoimmune disease. The damage can be found at multiple sites of the body, depending on the specificity of the hypersensitivity or autoimmune response. Special attention is needed to evaluate toxicity to the immune system in sensitive groups; responses may be modified by age, pregnancy, genetic make-up, and compromising conditions. © 2018 Elsevier Inc. All rights reserved. Subject Adaptive immunityAllergyAntigen processingAutoimmune diseaseDevelopmental immunotoxicity testing (DIT)Direct toxicityEnhanced histopathologyHost resistanceHypersensitivityIndirect toxicityInnate immunityInterspecies differencesLeukemiaLiverLymph nodesLymphoid depletionLymphoid proliferationLymphomaMucosa-associated lymphoid tissue (MALT)Neuroendocrine networkOmental adipose tissueSpleenStress reactionTertiary lymphoid tissuesThymusLifeMSB - Microbiology and Systems BiologyELSS - Earth, Life and Social Sciences To reference this document use: http://resolver.tudelft.nl/uuid:74dfe234-5e4d-4750-875b-e9eb628ca8d9 DOI https://doi.org/10.1016/b978-0-12-809841-7.00012-5 TNO identifier 787737 Publisher Elsevier, London ISBN 9780128098424 Source Fundamentals of Toxicologic Pathology, 273-313 Document type bookPart Files To receive the publication files, please send an e-mail request to TNO Library.