Print Email Facebook Twitter Alcohol consumption, mediating biomarkers, and risk of type 2 diabetes among middle-aged women Title Alcohol consumption, mediating biomarkers, and risk of type 2 diabetes among middle-aged women Author Beulens, J.W.J. Rimm, E.B. Hu, F.B. Hendriks, H.F.J. Mukamal, K.J. TNO Kwaliteit van Leven Publication year 2008 Abstract OBJECTIVE - The purpose of this study was to investigate whether adiponectin concentrations and biomarkers of inflammation, endothelial dysfunction, and insulin resistance mediate the association between alcohol consumption and diabetes. RESEARCH DESIGN AND METHODS - In a nested case-control study of 705 women with incident diabetes and 787 matched control subjects, we examined the adjusted relationship between baseline alcohol consumption and risk of diabetes before and after adjustment for markers of inflammation/endothelial dysfunction (C-reactive protein, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, tumor necrosis factor-α receptor 2, and interleukin-6), fasting insulin, and adiponectin concentrations. RESULTS- Alcohol consumption was associated with a decreased risk of diabetes (odds ratio per 12.5 g/day increment in alcohol use 0.58; 95% CI 0.49-0.69; P < 0.001). Adjustment for BMI attenuated the association by 25%. None of the markers of inflammation or fasting insulin appeared to account for >2% of the observed relationship. Without adjustment for BMI, these biomarkers individually explained slightly more of the association, but < 10% in all cases. Adiponectin accounted for 25% in a fully adjusted model and for 29% without adjustment for BMI. CONCLUSIONS - In this population of women, alcohol consumption was inversely associated with risk of type 2 diabetes. Adiponectin appeared to be a mediator of this association, but circulating biomarkers of inflammation, endothelial dysfunction, and fasting insulin did not explain this association. These results suggest that further research is needed into the potentially mediating roles of other biomarkers affected by alcohol consumption. © 2008 by the American Diabetes Association. Subject HealthPhysiological SciencesAdiponectinBiological markerC reactive proteinEndothelial leukocyte adhesion molecule 1InsulinIntercellular adhesion molecule 1Interleukin 6Tumor necrosis factor alpha receptorTumor necrosis factor alpha receptor 2Unclassified drugVascular cell adhesion molecule 1AdultAlcohol consumptionArticleBody massCase control studyControlled studyDisease associationEndothelial dysfunctionInflammationInsulin resistanceMajor clinical studyNon insulin dependent diabetes mellitusProtein blood levelBloodCoronary artery diseaseDiabetes mellitusDrinking behaviorPathophysiologyPhysiologyVascular endotheliumAdiponectinAdultAlcohol DrinkingBiological MarkersCoronary DiseaseDiabetes MellitusDiabetes Mellitus, Type 2Endothelium, VascularExerciseFemaleHumansInflammationInsulin ResistanceLife StyleMiddle AgedObesityPrevalenceQuestionnairesRisk FactorsSmoking To reference this document use: http://resolver.tudelft.nl/uuid:74996d93-dce5-4827-9108-871dfffd896d DOI https://doi.org/10.2337/dc08-0814 TNO identifier 241054 ISSN 0149-5992 Source Diabetes Care, 31 (10), 2050-2055 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.