Title
Toenail selenium status and the risk of Barrett's esophagus: The Netherlands Cohort Study
Author
Steevens, J.
Schouten, L.J.
Driessen, A.L.C.
Huysentruyt, C.J.R.
Keulemans, Y.C.A.
Goldbohm, R.A.
van den Brandt, P.A.
Publication year
2010
Abstract
Objective: To investigate the association between selenium and the risk of Barrett's esophagus (BE), the precursor lesion of esophageal adenocarcinoma. Methods: Data from the prospective Netherlands Cohort Study were used. This cohort study was initiated in 1986, when 120,852 subjects aged 55-69 years completed a questionnaire on dietary habits and lifestyle, and provided toenail clippings for the determination of baseline selenium status. After 16.3 years of follow-up, 253 BE cases (identified through linkage with the nationwide Dutch pathology registry) and 2,039 subcohort members were available for case-cohort analysis. Cox proportional hazards models were used to calculate incidence rate ratios (RR). Results: The multivariable-adjusted RR for the highest versus the lowest quartile of toenail selenium was 1.06 (95% CI 0.71-1.57). No dose-response trend was seen (p trend = 0.99). No association was found in subgroups defined by sex, smoking status, body mass index (BMI), or intake of antioxidants. For BE cases that later progressed to high-grade dysplasia or adenocarcinoma, the RR for a selenium level above the median vs. below the median was 0.64 (95% CI 0.24-1.76). Conclusions: In this large prospective cohort study, we found no evidence of an association between selenium and risk of BE. © 2010 The Author(s).
Subject
Human
LS - Life Style
BSS - Behavioural and Societal Sciences
Health
Barrett esophagus
Biological markers
Selenium
To reference this document use:
http://resolver.tudelft.nl/uuid:737abeb8-63c3-4acd-95a3-e65e7732568a
DOI
https://doi.org/10.1007/s10552-010-9651-1
TNO identifier
426838
ISSN
0957-5243
Source
Cancer Causes and Control, 21 (12), 2259-2268
Document type
article