Title
The possibilities of the use of N-of-1 and do-ityourself trials in nutritional research
Author
Krone, T.
Boessen, R.
Bijlsma, S.
van Stokkum, R.
Clabbers, N.D.S.
Pasman, W.J.
Publication year
2020
Abstract
Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the differences of three popular statistical methods in analyzing treatment effects of data obtained in N-of-1 designs. Method. We compare Individual-participant data meta-analysis, frequentist and Bayesian linear mixed effect models using a simulation experiment. Furthermore, we demonstrate the merits of the Bayesian model including prior information by analyzing data of an empirical study on weight loss. Results. The linear mixed effect models are to be preferred over the meta-analysis method, since the individual effects are estimated more accurately as evidenced by the lower errors, especially with lower sample sizes. Differences between Bayesian and frequentist mixed models were found to be small, indicating that they will lead to the same results without including an informative prior. Conclusion. For empirical data, the Bayesian mixed model allows the inclusion of prior knowledge and gives potential for population based and personalized inference.
Subject
meta analysis (topic)
adult
body weight loss
controlled study
empiricism
female
male
meta analysis
nutritional science
sample size
simulation
Bayes theorem
computer simulation
meta analysis (topic)
methodology
nutrition
nutritional science
procedures
statistical model
Bayes Theorem
Computer Simulation
Humans
Linear Models
Meta-Analysis as Topic
Nutritional Physiological Phenomena
Nutritional Sciences
Research Design
Sample Size
To reference this document use:
http://resolver.tudelft.nl/uuid:731673f9-1685-4b39-901e-9b20e037560a
DOI
https://doi.org/10.1371/journal.pone.0232680
TNO identifier
876041
Source
Plos One, 15 (15), e0232680
Document type
article