Print Email Facebook Twitter The growth inhibiting effect of docetaxel (Taxotere®) in head and neck squamous cell carcinoma xenografts Title The growth inhibiting effect of docetaxel (Taxotere®) in head and neck squamous cell carcinoma xenografts Author Medisch Biologisch Laboratorium TNO Braakhuis, B.J.M. Kegel, A. Welters, M.J.P. Publication year 1994 Abstract Docetaxel (Taxotere®) is a new antitumor agent with activity in patients with ovarian, lung and breast cancer. In this study, docetaxel was tested for its antitumor effect in human tumor xenografts derived from head and neck squamous cell carcinoma (HNSCC). A significant growth inhibiting effect was observed in the two tested lines, at the well tolerated dose of 20 m/kg docetaxel. Two intravenous injections were given with a week interval. Both lines were less sensitive to treatment with cisplatin, indicating that no cross-reactivity exists between these drugs. Docetaxel has a promising outlook in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Chemicals/CAS: Antineoplastic Agents, Phytogenic; Cisplatin, 15663-27-1; docetaxel, 114977-28-5; Paclitaxel, 33069-62-4 Subject Antitumor effectDocetaxelHead and neck cancerSquamous cell carcinomaTaxolTaxotere®antineoplastic agentcisplatindocetaxelanimal experimentanimal modelarticlecancer inhibitioncell growthcontrolled studydrug cross reactivityfemalehead cancerintravenous drug administrationmouseneck cancernonhumanpriority journalsquamous cellsquamous cell carcinomatumor xenograftAnimalAntineoplastic Agents, PhytogenicCarcinoma, Squamous CellCell LineCisplatinComparative StudyFemaleHead and Neck NeoplasmsHumanMiceMice, NudeNeoplasm TransplantationPaclitaxelSupport, Non-U.S. Gov't To reference this document use: http://resolver.tudelft.nl/uuid:70eb0666-09b0-4acb-9569-e0786588d974 DOI https://doi.org/10.1016/0304-3835(94)90196-1 TNO identifier 232638 ISSN 0304-3835 Source Cancer Letters, 81 (81), 151-154 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.