Print Email Facebook Twitter Dialysis-solid-phase extraction combined on-line with non-aqueous capillary electrophoresis for improved detectability of tricyclic antidepressants in biological samples Title Dialysis-solid-phase extraction combined on-line with non-aqueous capillary electrophoresis for improved detectability of tricyclic antidepressants in biological samples Author Veraart, J.R. Brinkman, U.A.Th. Centraal Instituut voor Voedingsonderzoek TNO Publication year 2001 Abstract Dialysis-solid-phase extraction (SPE) sample pretreatment is combined on-line with non-aqueous capillary electrophoresis for the determination of tricyclic antidepressants in urine and serum. After clean-up and enrichment, the water is removed from the sample matrix and the analytes are eluted from the cartridge by means of an organic solvent. Next, the eluate is transported to the capillary and the injection is performed electrokinetically. This injection, which does not suffer from an adverse sample matrix effect because of the SPE step, results in further analyte concentration. The detection limits are in the 0.02-0.1 μg/ml range and the day-to-day repeatabilities are between 2.5 and 9.5%, which is quite satisfactory. © 2001 Elsevier Science B.V. All rights reserved. Chemicals/CAS: Antidepressive Agents, Tricyclic Subject BiologyAntidepressive Agents, TricyclicElectrophoresis, CapillaryHumansReproducibility of ResultsSensitivity and Specificity To reference this document use: http://resolver.tudelft.nl/uuid:70e786ed-d413-4ddf-870f-ff414df8421d DOI https://doi.org/10.1016/s0021-9673(01)00873-1 TNO identifier 72582 ISSN 0021-9673 Source Journal of Chromatography A, 922 (1-2), 339-346 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.