Title
Dialysis-solid-phase extraction combined on-line with non-aqueous capillary electrophoresis for improved detectability of tricyclic antidepressants in biological samples
Author
Veraart, J.R.
Brinkman, U.A.Th.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2001
Abstract
Dialysis-solid-phase extraction (SPE) sample pretreatment is combined on-line with non-aqueous capillary electrophoresis for the determination of tricyclic antidepressants in urine and serum. After clean-up and enrichment, the water is removed from the sample matrix and the analytes are eluted from the cartridge by means of an organic solvent. Next, the eluate is transported to the capillary and the injection is performed electrokinetically. This injection, which does not suffer from an adverse sample matrix effect because of the SPE step, results in further analyte concentration. The detection limits are in the 0.02-0.1 μg/ml range and the day-to-day repeatabilities are between 2.5 and 9.5%, which is quite satisfactory. © 2001 Elsevier Science B.V. All rights reserved. Chemicals/CAS: Antidepressive Agents, Tricyclic
Subject
Biology
Antidepressive Agents, Tricyclic
Electrophoresis, Capillary
Humans
Reproducibility of Results
Sensitivity and Specificity
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DOI
https://doi.org/10.1016/s0021-9673(01)00873-1
TNO identifier
72582
ISSN
0021-9673
Source
Journal of Chromatography A, 922 (1-2), 339-346
Document type
article