Print Email Facebook Twitter Aortic pressure-area relation in Marfan patients with and without β blocking agents: A new non-invasive approach Title Aortic pressure-area relation in Marfan patients with and without β blocking agents: A new non-invasive approach Author Nollen, G.J. Westerhof, B.E. Groenink, M. Osnabrugge, A. van der Wall, E.E. Mulder, B.J.M. TNO Industrie Publication year 2004 Abstract Objective: To investigate the heterogeneous response to β blockade in patients with Marfan syndrome by non-invasive assessment of the aortic pressure-area curve. Design and patients: 25 patients with the Marfan syndrome who used β blocking agents (mean (SD) age, 29 (10) years; 20 men, five women), seven without β blockade (34 (14) years; five men, two women), and 10 controls (29 (5) years; seven men, three women) underwent magnetic resonance imaging and non-invasive continuous blood pressure measurement. Pressure-area curves were constructed at the level of the descending thoracic aorta. A transition point was defined as the pressure at which the pressure-area relation deviated from its elastic (linear) to the collagen (exponential) course. Setting: Tertiary referral centre for adult congenital heart disease. Results: In six patients (five with and one without β blockade), a transition point in the pressure-area curve was observed, indicating that the load bearing component was not only elastin but also collagen. In the remaining 26 Marfan patients and in the control subjects a linear pressure-area relation was observed. Conclusions: This new non-invasive method to derive aortic pressure-area curves showed that most patients with Marfan syndrome have a similar pressure-area curve to controls with similar blood pressures. Five patients on β blockade showed a transition point in the pressure-area curve which could play a crucial role in the heterogeneous response to β blocker treatment in Marfan patients. Patients with a transition at low blood pressures may not benefit from β blocking agents. Subject Beta adrenergic receptor blocking agentBlood pressure monitoringCongenital heart diseaseLesions and defectsMarfan syndromeNuclear magnetic resonance imagingPathologyPathophysiologyPhase transitionPhysiologyThoracic aortaAdrenergic beta-AntagonistsAortic DiseasesDilatationMagnetic Resonance Angiography To reference this document use: http://resolver.tudelft.nl/uuid:706a866e-c311-4b9c-ba39-cda76907f915 TNO identifier 280243 ISSN 1355-6037 Source Heart, 90 (3), 314-318 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.