Print Email Facebook Twitter Lipoprotein (a): Relation to other risk factors and genetic heritability; results from a Dutch parent-twin study Title Lipoprotein (a): Relation to other risk factors and genetic heritability; results from a Dutch parent-twin study Author Boomsma, D.I. Kaptein, A. Kempen, H.J. Gevers Leuven, J.A. Princen, H.M. Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO Publication year 1993 Abstract We measured plasma levels of lipoprotein(a) (Lp(a)) in a sample of 152 Dutch adolescent mono- and dizygotic twin pairs and their parents. The distribution of Lp(a) levels was skewed, with the highest frequencies at low levels and was similar for adult men and women and their children. The relationship of Lp(a) concentrations with other lipoprotein and apolipoprotein risk factors for coronary heart disease and with lathosterol, an indicator of whole-body cholesterol synthesis, was studied dependent on sex and generation. In mothers and children there was a small positive correlation between Lp(a) levels and plasma cholesterol and apolipoprotein (apo) B. In mothers and daughters there also was a correlation between Lp(a) and LDL cholesterol levels. No correlation was found between Lp(a) levels and plasma lathosterol, suggesting that there is no relationship between Lp(a) levels and cholesterol synthesis. Associations among family members, i.e. between monozygotic and dizygotic twins and between parents and offspring were used to study familial transmission of Lp(a) levels. Results showed that almost all of the variance in Lp(a) concentrations was accounted for by genetic heritability. A small, but significant, sex difference in heritability was observed, but heritabilities were the same in parents and offspring. Heritability estimates were 93% for females and 98% for males. No evidence was found for assortative mating or for the influence of a shared family environment. These results indicate that nearly all variance in Lp(a) concentrations that is not accounted for by the apo(a) size polymorphism, is also under genetic control. Subject Health To reference this document use: http://resolver.tudelft.nl/uuid:6f0ec74d-3208-49f7-8fbf-695d7bfc082d TNO identifier 280997 Source Atherosclerosis, 99, 23-33 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.